Mach source, compound type, precursor, chemistry

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Author:
jcu1
ID:
258361
Filename:
Mach source, compound type, precursor, chemistry
Updated:
2014-01-25 18:02:54
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Schiff
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Description:
Oncology natural products
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  1. vinblastine source
    Madagascar Periwinkle
  2. vinblastine and vincristine structure
    • bisindole alkaloid
    • indole-dihydroindole
  3. vinblastine indole nitrogen and acids
    doesn't form salts with acids
  4. vinblastine dihydroindole and acids
    forms salts with acids
  5. vinblastine color
    white/colorless
  6. vincristine source
    Madagascar periwinkle
  7. difference between vincristine and vinblastine structure
    • vincristine has N1 CHO
    • vinblastine has N1 CH3
  8. vinorelbine
    Semi-synthetic from vinblastine
  9. vinorelbine chemistry
    • same as vinblastine, except without CH2 group at C8
    • and dehydration across C3' and C4' bond
  10. vinorelbine salt
    water soluble tartrate
  11. vincristine and vinblastine salt
    water soluble sulfate salt
  12. vintafolide source
    • investigational
    • semi-synthetic from vinblastine
    • orphan drug status in EU
  13. vintafolide chemistry
    • peptide side chain at C3
    • deacetyl at C4

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