Onco Natural products MOA

Card Set Information

Author:
jcu1
ID:
258366
Filename:
Onco Natural products MOA
Updated:
2014-01-25 18:32:09
Tags:
Schiff
Folders:
Schiff
Description:
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  1. Vinca alkaloid/derivative drugs and MOA
    • vinblastine, vincristine, vinorelbine, vintafolide
    • inhibits microtubule funtion
    • binds to tubulin the promote microtubule dissolution
  2. camptotheca alkaloids drugs and MOA
    • camptothecan, topotecan, irinotecan
    • stabilize the bond of topoisomerase I to DNA
    • intercalates DNA at cleavage site, mimicking a DNA base pair
  3. Taxus alkaloids drugs and MOA
    • Paclitaxel, docetaxel, larotaxel, cabazitaxel, tesetaxel
    • stabilizes microtubules
    • prevents depolymerization of tubule into mitotic spindle

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