Top 200 drugs

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Author:
Jjanggoo83
ID:
258384
Filename:
Top 200 drugs
Updated:
2014-01-27 00:15:14
Tags:
Analgesics Antidiabetic
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top 200 drugs
Description:
ch 1-2
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  1. Acetaminophen

    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Tylenol, Paracetamol, Ofirmev (injectable),etc
    • injection- Rx only,
    • Tab( chewable, Disintegrating, ER), caps, gelcap, elixir, solution, suspension, suppository, injection
    • mild pain -HA, ARthritis, fever
    • mod- severe- combined w/ other analgesics
    • preg B(po)/C (inj)
    • 500-650mg q 4-6hr prn
    • max. 4g/day, 3g for chronic use
    • children<12yrs:10-15mg q 4-6 hrs prn
    • do not exceed 5 dose in 24hr
    • renal impair- less frequent, liver-2g/day for chronic alcoholics
    • ADR- hepatotoxicity @ excessive. non toxic @ therapeutic
    • DI- carbamazepine, ethanol (>3drinks), isoniazid, phenytoin, warfarin
    • CI- hypersensitivity, severe hep. impair pts
    • note: preferred during pregnant, breastfeeding
  2. Butalbital w/ Caffeine&  Acetaminophen 

    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
  3. brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
  4. brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
  5. brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
  6. brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
  7. brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
  8. Oxycodone
    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Oxycontin, OxyIR,Roxicodone
    • C II narcotic, 
    • cap, oral liquid, concentrate, IR, CR
    • mod-severe pain
    • init 50mg po q 4-6 hr; 10mg ER q 12hr (naive)
    • maintenance- 20-160mg q12h; no max
    • ADR- constipation, n/v, dizziness, xerostomia, pruritus (histamine release); rare/severe- hallucination, hpotension, respiratory/CNS depression
    • MI-CNS depressants, MAO-I, SSRIs
    • CP- drowsiness, avoid, constipation (laxative), discontinuation; combo w/ apap or ibu
    • note: only PO, CR not for acute**death if abuse after crushing SR tablet
  9. Tapentadol
    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Nucynta, Nucynta ER
    • C II narcotic
    • tab, ER
    • mod-sever pain
    • prg C
    • dose- 50-100 q 4-6 for acute;(max 700 then 600mg);ER 50mg q 12h for chronic (max 500)
    • dec. dose for hepatic impair; not recommend for severe renal & hepatic impair
    • ADR-sedation, hypotension, n/v, constipation,pruritus; rare/severe- S syndrome, seizure,  respiratory depression
    • DI- alcohol, CNS depressant, SSRI, MAOI, naloxone (seizure)
    • CP- drowsines, alcohol, discontinuation, no refill
    • note- only po; ER not for acute or postoperative pain; guide @ dispense; ct w/ seizure hx
  10. Tramadol
    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Ultram, Conzip, Ultracet, Ultram ER, Rybix ODT 
    • analgesic Norcotic
    • IR, ER, ODT, ultracet is combo w/ actaminophen
    • mod-severe pain*, neuropathic pain
    • prg C
    • initial 50mg q4-6; main.50-100mg; max 400/day (300 ER); renal&hepatic q 12h
    • ADR-sedation,dizziness, constipation, n/v, somnolence, euphoria/dysphoria
    • rare (hypotension, seizure @ >500mg/day (discontinuation)
    • MI-carbamazepine(dec. level), mao inhibitor, TCA, SSRI (S syndrome), naloxone (seizure)
    • CP- w/ d syndrome, drowsiness NOT CONTROLLED (but abuse pot), caution w/ sz hx
  11. Codeine/Acetaminophen

    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Capital & codeine, Tylenol2, Tylenol 3, Tylenol 4, Tylenol w/ Codeine
    • tabs- C III; solution- C V
    • Analgesics- nacotic/non-narcotic
    • tabs, oral solution
    • mild-mod*; antitussive
    • prg C
    • dose:Adult- antitussive: 15-30mg q 4-6 hr; pain- 30-60mg q4-6
    • max 4g/ 2g for chronic alcoholics
    • children: 0.5-2mg codeine/kg per dose q 4-6h (5,10,15ml q 6,6,4)
    • renal reduction; hepatic adjust- limit acetaminophen to <2g and avoid if cirrohis pts
    • ADR- constipation, n/v, sedation, dizziness, xerostomia, pruritus
    • rare/severe- hallucination, hypotension, respiratory and cns depression, hepatotoxicity
    • DI- CYP2D6 inhibitors, CNS depressants, ethanol use, Isoniazid, warfarin
    • cp- drowsiness, laxative may b needed, discontinuation, dependence,
    • note: differ in individual metabolism (converting codeine to active metabolite)
  12. Hydrocodone/Acetaminophen 
    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Lorcet, Lortab, Norco, Vicodin, Zydone, etc
    • analgesic- narcotic/non narcotic
    • C III
    • Tab, cap, oral solution
    • moderate pain
    • preg. C
    • Adult: 1-2 tabs q 4-6 hours ; 5-10ml elixir q 4-6 hr; Children (<50kg):0.1-0.2mg/kg per dose hydrocodone component q 4-6 hr
    • max (4g of acetaminophen; 2g for alcoholics)
    • ADR: constipation, n/v, sedation, dizziness,xerostomia, pruritus (histamine release); rare/severe-hallucination, hypotension, respiratory and cns depression, hepatotoxicity (exceeding acet. dose)
    • DI- cns depressant, ehtanol (>3), isoniazid, warfarin, cns depressant
    • CP- drowsiness, discontinuation, alchol, constipation
  13. Hydrocodone/ Ibuprofen
    • Vicoprofen, Ibudone, Reprexain 
    • C II
    • Tablet
    • moderate pain 
    • prg. C
    • adult dose: 1 tabs q 4-6 hr
    • max: 5 tabs / day 
    • ADR-  constipation, n/v sedation, dizziness, xerostomia, pruritus, dyspepsia (indigestion) ;rare/severe-hypotension, hallucination, respiratory and cns dep. edema, renal impair, GI bleeding (ulcers,etc) increased bp
    • DI- CNS depressant,  affect to anticoagulant, antihypertensive, aspirin, cns depressant, Li, MAO inhibitor + SSRI - serotonin synd.
    • CI-asthma, urticaria, allergic rxn to aspirin / nsaids, perioperative pain in CABG surgery

    CP- abrupt discontinuation, drowsiness, etc.
  14. Oxycodone/Acetaminophen
    • Endocet, Percocet, Roxcet, Tylox 
    • C II 
    • cap, caplet, tablet, oral liquid
    • mod-severe pain 
    • initial dose- 1-2 tabs q 4-6 hrs
    • oral solution- 5-10ml q 4-6 h
    • max dose 3g acetaminophen (2g for alcoholic)
    • DI- warfarin, cns depressant, ethanol, isoniazid, 
    • CP- drowsiness, constipation, alcohol 
    • note: RX should include strength desired*
  15. Celecoxib

    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Celebrex, NSAIDs (Selective Cox 2 inhibitor)
    • rx only; caps
    • Osteoarthritis*, ankylosing spondylitis, juvenile idiopathic arthritis (JIA), rheumatoid RA, mangement of acute pain (mild), primary dysmenorrehea
    • preg. C/ D (at term)
    • 200mg/day po in bid, increase 400mg in 6 wks
    • (if no effect in 6wks , discontinue)
    • dysmenorrhea- 400mg initial (+200) 1st day,
    • 200mg tid 
    • severe renal / hepatic- not recommended; moderate hepatic- reduce 50% 
    • ADR: N, GI ulcer (less), hypertension, HA, diarrhea, peripheral edema
    • rare/severe- GI bleeding, perforation,SJ syndrome, MI and stroke, thrombosis, renal toxicity, toxic epidermal necrolysisk dermatitis, hepatitis, liver fx, ARF
    • DI- antacid, corticosteroid, ehtanol, fluconazole, 
    • affecting on ACEi, ARB, anticoagulants, aspirin, cyclosporin, diuretic, lithium
    • CI- perioperative after CABG surgery ; hypersensitivity to NSAIDS, celecoxib, sulfonamide, aspirin, other NSAIDs
    • CP- S/Sx of GI bleeding, take w/ food if GI 
    • CV risk incresase
    • note- caution w/ fluid retension, CHF, renal insufficiency, HTN, elderly increased risk for GI ulcer, CNSeffect, renal toxicity 
    • hypersensitivity to sulfonamides (nonantibiotic sulfonamides)should avoid
    • do not use pts w/ bronchospasm, asthma, rhinitis or urticaria w/ nsaids or aspirin 
    • BBW: inc. risk for thrombosis, stroke, MI
    • - doesnt inhibit platelet or prolong bleeding time; caution w/ hx of GI; concurrent tx w/ aspirin, anticoagulant, corticosteroids, smoking, alcohol, elderly
  16. NSAIDS  in general class
    MOA
    ADR
    DI 
    CI
    CP
    note
    • MOA:prostaglandin synthesis inhibited by dec. cox 1& cox 2 activity (inflammation and pain associated to prostaglandin precursors)
    • ADR- n/gastritis, abdominal cramps, gi ulcers, peripheral edema, hypertension, diarrea
    • rare/severe- GI prforation bleeding, renal toxicity, ARF, angioedema, bronchoconstriction, asthma rash, tinnitus, hearing loss
    • DI- corticosteroid(inc. GI SE) ethanol 
    • affecting on ACE/ARB; anticoagulant, antiplatelet therapy , BB, digoxin (inc level), diuretic, heparin, warfarin, lithium 
    • CI- hypersensitivity to aspirin or NSAIDs, perioperative pain w/ CABG, peptic ulcer disease
    • CP- GI sx, take w/ food if GI upset, abnormal swelling or bleeding, may inc. CV risk (except aspirin)
    • may worsen fluid retention, CHF, renal insufficiency, HTN, may increase risk for MI, thrombosis, stroke, elderly (inc. risk GI, CNS SE, renal SE) ; aspirin triad (bronchial asthma, aspirin intolerance, rhinitis)
  17. Aspirin
    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Bayer Buffierin, Ecotrin, Excedrin, etc
    • Enteric coated, buffered, chewable, CR, gum suppository 
    • preg- no catgory, CI except low dose
    • adult
    • antiplatelet: 50-325mg daily
    • pain& inflammation: 325-650mg q 4-6h max 4g/day
    • pediatric: antipyretic, analgesic: 10-15mg/kg/dose q 4-6h upto 4g/day  PO, rectal
    • antiinflammatory- initial 60-90mg/kg per day po
    • renal / hepatic sever impairment- avoid use
    • ADR- Reye's syndrome (children)
    • DI- ginkgo(inc. antiplatelet E), NSAIDS (inc. bleeding)
    • affecting on ACEi, anticoagulants
    • CI- salicylate NSAIDs hypersensitivity, nasal polyps, bleeding disorder (factor deficiency), NO <16yrs for viral infections (chickenpox / flu sx), w/ or w/o fever= Reye's syndrome 
    • CP: high dose for short term pain. any bleeding sx, take w/ food or milk
    • stop 1wk prior to surgery (bleeding!)
  18. Diclofenac
    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Flector, Voltaren, pennsaid, Solaraze
    • NSAIDs ; RX only 
    • caps, tab, delayed release enteric tab, ER, topical gel, topical solution, transdrmal patch ophthalmic solution
    • preg B for topical gel 3%; C-oral, 1% gel, topical solution, topical patch; D- for PO, topical solution at term (>=30wks)
    • dose analgesia- 50mg po tid, dysmenorrhea 150-200mg; same for RA; instill 1-2 drops; patch- 1 patch daily 
    • CI- hypersensitivity to bovine protein 
    • rest ADR, counseling for general NSAIDs
  19. Etodolac
    brand; class; OTC; dosage form; indication; Pregnancy; dose; ADR; DI; couseling; note
    • Lodine
    • NSAIDs
    • Rx only
    • tab, caps, ER, 
    • acute for mild- mod. RA, osteoarthritis
    • preg. C
    • dosing : acute- 200-400 q 6-8 max- 1000mg/day; RA IR- 400bid or 300 tid, 500 bid
    • wt dosing 400-1000mg daily for children (6-16yr) for juvenile RA
    • Avoid in severe renal impair
    • CP- GI bleeding, take w/ food if GI, abnormal swelling, inc. CV risk

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