Pharmacology - Aminoglycosides 2

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  1. What bacteria are in the spectrum f aminoglycosides?
    Enterobacteriaceae (e. coli, enterbacter species, klebsiella pneumonia, Serratia, Proteus) Pseudomonas aeruginosa and Acinitobacter
  2. With a lung infection, particularly when treating pseudomonas or acinitobacter, how should you design your treatment with an aminoglycoside?
    Give with a cell wall inhibitor, like a PCN
  3. What are the indications for streptomycin?
    Used to be TB, but lots of resistance now. Currently: Bubonic plague and lularemia
  4. How would you design a treatment for enterococci using gentamicin?
    Give with a PCN
  5. Is resistance a problem with gentamicin?
    Yes, though less than streptomycin due to extra substituents
  6. Why should you test for resistance before administering gentamicin?
    Resistance is becoming very common
  7. What is Gentamicin generally used for?
    Serious gram negative infections
  8. What is the main toxicity of streptomycin?
    Fibular toxicity
  9. What is the main toxicity of gentamicin?
    Fibular toxicity
  10. Under what conditions can Gentimicin treat a MRSA infection?
    When used in combonation with a cell wall inhibitor
  11. Why is t beneficial/synergistic to use a cell wall inhibitor with an aminoglycoside?
    Because the cell wall inhibitor helps break down the cell wall and allow the aminoglycoside to enter
  12. When treating aMRSA infection, would you use gentamicin and a penicillin the same IV bag for synergistic effect?
    No, they interact in the same bag and bind together
  13. Is tobramycin useful against Enterococcus faecium?
  14. Is tobramycin usedful against mycobacteria?
  15. Which aminoglycoside is tobramycin often used interchangeably with and why?
    Gentimycin, similar spectrum
  16. Is gentamycin or tobramycin used for TB infections?
  17. In what form could tobramycin be given to potentially treat Pseudomonas infections?
  18. Is kanamycin a first line drug therapy, why or why not?
    No, because it is very toxic, can cause permanent hearing loss (audio/vestibular toxicity)
  19. Does Kanamycin have high or low activity against most bacteria?
  20. What is the main prescription use for Kanamycin?
    2nd like therapy for mycobacterium tuberculosis
  21. When bacteria are resistant to gentamycin and tobramycin what antibiotic would you likely use and why?
    Amikacin, because it is more resistant to enzymatic breakdown due to extra substituents
  22. Which aminoglycoside has the broadest spectrum?
  23. What is Amikacin useful for treating?
    2nd line for TB, also treats P. aeruginosa, Serratia, Proteus, Kelbiella and E. coli among many others
  24. What is Amikacin derived from?
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Pharmacology - Aminoglycosides 2
2014-01-27 04:15:17
Pharmacology Aminoglycosides

Pharmacology - Aminoglycosides 2
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