- produced by?
- binds to?
- causes what?
- effective on gram (-)/ (+)?
- bactericidal? bacteriostatic?
–produced by Bacillus polymyxis
–binds to membrane phospholipids
- causes cleavages (openings) in cell membrane, resulting in loss of cell contents
–effective mainly against gram-negative bacteria;
- cannot effectively diffuse through the thick peptidoglycan layer in gram-positives
–usually limited to topical usage