Pharmacokinetics
Home > Flashcards > Print Preview
The flashcards below were created by user
Anonymous
on
FreezingBlue Flashcards. What would you like to do?

How do you work out the volume of distribution?
V_{d} = total amount of drug / concentration of drug in plasma

What is the approximate volume of distribution for a drug that is distributed in a) plasma b) ECF c) total body water d) more than total body water
 a) 0.005l/kg
 b) 0.2 l/kg
 c) 0.55 l/kg
 d) >1l/kg

How do we work out a loading dose?
Loding dose = V_{d} x C_{eff}

What are some of the factors affecting volume of distribution?

What are the two core metabolic processes?
 Phase 1 reactions  functionalisation
 Phase 2 reactions  conjugation

What is the main function of metabolism?
To increase the water solubility of a molecules to make it easier for them to be excreted.

Some drugs can induce the synthesis of microsomal enzymes. What are the results of this?
 Increased metabolism
 Can increase or decrease toxicity

What are some of the factors that can affect metabolism?
 Previous drug therapy
 Age
 Disease
 Species
 Interindividual variation

What is clearance?
The efficiency of the irreversible elimination of a drug from the systemic circulation Or the volume of blood cleared of a drug per unit time

What is zero order kinetics?
When the concentration of a drug declines linearly over time

What is first order kinetics?
When the concentration of a drug declines exponentially with time

What is K_{abs}?
The rate constant for absorption

What is K_{exc}?
The rate constant for excretion

What is K_{met}?
The rate constant for metabolism

What is C_{(t)}?
The concentration at time 't'

What is Cl_{s}?
Total clearance of the drug

What is half life?
The amount of time required for a quantity to fall to half its value as measured at the beginning of the time period