Pharmacology - Antifungals 1

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kyleannkelsey
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259123
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Pharmacology - Antifungals 1
Updated:
2014-01-29 17:09:37
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Pharmacology Antifungals
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Pharmacology - Antifungals 1
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Pharmacology - Antifungals 1
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  1. Except for flucytosine and griseofluvin, all currently available antifungals have what target?
    Fungal cell membrane or cell wall
  2. Why do most anti-fungals target the membrane or cell wall?
    Because funal cell wall/membrane contain ergosterol instead of cholesterol, a differentiated target
  3. What drugs are the Polyene’s?
    Amphotericin B and Nystatin
  4. How is Amphotericin B mainly administered?
    IV, systemically
  5. What pH is Amphotericin B most active at and why?
    6-7.5 pH, at which it is in a neutral form and is most lipophilic
  6. How did Amphotericin B get its name?
    It has a N and COOH group that make it amphoteric
  7. Can Amphotericin be used in pregnant women?
    Yes
  8. Is Amphotericin B broad ort narrow spectrum?
    Broad
  9. What is the MOA for Amphotericin B?
    Binds to ergosterol in membrane and increases permeability to K and Mg to leak out ( creates pores)
  10. How would you administer Amphotericin B if you want to use it systemically and why?
    IV, not absorbed by GI
  11. In what (rare) instance might you use Amphotericin B orally?
    Infection of the lumen of the GI
  12. Does Amphotericin B penetrate the CSF?
    No
  13. Would hepatic or renal impairment affect serum levels of Amphotericin B?
    No
  14. Is Amphotericin B effective topically?
    No
  15. How would you administer Amphotericin B for a meningeal infection?
    Intrathecally (because does not penetrate the CSF systemically)
  16. Does Amphotericin B inhibit CYP450 enzymes?
    No
  17. Would Amphotericin B be used for empiric therapy of a severe fungal infection?
    Yes
  18. What fungi can be treated with Amphotericin B?
    Most: Candidiasis, aspergillosis, cryptococcosis, mucormycosis (zygomycosis), blastomycosis, protozoa (Leishmania genus) causing leishmaniasis
  19. What is the pregnancy category for Amphotericin B?
    B
  20. What types of formulations are available for Amphotericin B?
    Conventional and lipid based formulation
  21. C-AMB (Amphotericin B deoxycholate) is what formulation of Amphotericin B?
    Conventional
  22. What does AMCD stand for?
    Amphotericin B colloidial dispersion, a lipid based formulation
  23. What does LAmB stand for?
    Liposomal Amphotericin B
  24. What does ABLC stand for?
    Amphotericin B lipid complex
  25. Why does Amphotericin B come in lipid based formulation?
    To reduce nephrotoxicity associated with Amphotericin B’s lipophilic adherence to nephron cell membranes
  26. Is Amphotericin B used for moderate or severe systemic infections?
    Severe
  27. What are the main side effect sof Amphotericin B?
    Mammalian membrane interactions, infusion related Fever/chills/HA/N/phlebitis/spasms, allergies/anaphylaxis, , hypochromic cormocytic anemia, renal toxicity, hypokalemia and hypomagnesemia
  28. What is the primary side effect of Amphotericin B?
    Nephrotoxicity

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