Pharmacology - Antifungals 1

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  1. Except for flucytosine and griseofluvin, all currently available antifungals have what target?
    Fungal cell membrane or cell wall
  2. Why do most anti-fungals target the membrane or cell wall?
    Because funal cell wall/membrane contain ergosterol instead of cholesterol, a differentiated target
  3. What drugs are the Polyene’s?
    Amphotericin B and Nystatin
  4. How is Amphotericin B mainly administered?
    IV, systemically
  5. What pH is Amphotericin B most active at and why?
    6-7.5 pH, at which it is in a neutral form and is most lipophilic
  6. How did Amphotericin B get its name?
    It has a N and COOH group that make it amphoteric
  7. Can Amphotericin be used in pregnant women?
  8. Is Amphotericin B broad ort narrow spectrum?
  9. What is the MOA for Amphotericin B?
    Binds to ergosterol in membrane and increases permeability to K and Mg to leak out ( creates pores)
  10. How would you administer Amphotericin B if you want to use it systemically and why?
    IV, not absorbed by GI
  11. In what (rare) instance might you use Amphotericin B orally?
    Infection of the lumen of the GI
  12. Does Amphotericin B penetrate the CSF?
  13. Would hepatic or renal impairment affect serum levels of Amphotericin B?
  14. Is Amphotericin B effective topically?
  15. How would you administer Amphotericin B for a meningeal infection?
    Intrathecally (because does not penetrate the CSF systemically)
  16. Does Amphotericin B inhibit CYP450 enzymes?
  17. Would Amphotericin B be used for empiric therapy of a severe fungal infection?
  18. What fungi can be treated with Amphotericin B?
    Most: Candidiasis, aspergillosis, cryptococcosis, mucormycosis (zygomycosis), blastomycosis, protozoa (Leishmania genus) causing leishmaniasis
  19. What is the pregnancy category for Amphotericin B?
  20. What types of formulations are available for Amphotericin B?
    Conventional and lipid based formulation
  21. C-AMB (Amphotericin B deoxycholate) is what formulation of Amphotericin B?
  22. What does AMCD stand for?
    Amphotericin B colloidial dispersion, a lipid based formulation
  23. What does LAmB stand for?
    Liposomal Amphotericin B
  24. What does ABLC stand for?
    Amphotericin B lipid complex
  25. Why does Amphotericin B come in lipid based formulation?
    To reduce nephrotoxicity associated with Amphotericin B’s lipophilic adherence to nephron cell membranes
  26. Is Amphotericin B used for moderate or severe systemic infections?
  27. What are the main side effect sof Amphotericin B?
    Mammalian membrane interactions, infusion related Fever/chills/HA/N/phlebitis/spasms, allergies/anaphylaxis, , hypochromic cormocytic anemia, renal toxicity, hypokalemia and hypomagnesemia
  28. What is the primary side effect of Amphotericin B?
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Pharmacology - Antifungals 1
2014-01-29 22:09:37
Pharmacology Antifungals
Pharmacology - Antifungals 1
Pharmacology - Antifungals 1
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