Pharmacology - Antifungals 3

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kyleannkelsey
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259126
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Pharmacology - Antifungals 3
Updated:
2014-01-29 17:11:57
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Pharmacology Antifungals
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Pharmacology - Antifungals 3
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Pharmacology - Antifungals 3
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  1. What are the adverse effect of Flucytosine?
    N/V, colitis, Bone marrow suppression, thrombocytopenia, alopecia, hepatotoxicity
  2. What sub-categories of drugs fall into the category of Azoles?
    Imidazoles and Triazoles
  3. What is the MOA for Azoles?
    Inhibits synthesis of ergosterol by inhibiting 14-alpha demethylase, blocking lanosterol demethylation
  4. What type of Azole is Ketoconazole?
    Imidazole
  5. Do azoles inhibit cytochromes?
    Yes
  6. Are azoles broad or narrow spectrum?
    Broad
  7. Which Azoles are teratogenic?
    All
  8. Which Azoles inhibit CYP450s?
    All
  9. What pH is important for ketoconazole absorption and knowing this, how should you counsel your patients accordingly?
    Acidic pH, don’t take antacids/PPI, etc.
  10. What are the side effects of ketoconazole?
    N/V, allergies, hormonal imbalance (odd menses/static spermatogenesis), fluid retention and Hepatitis
  11. Does ketoconazole cross the BBB?
    No
  12. Itraconazole is what type of azole?
    Triazole
  13. Is Itraconazole broad or narrow spectrum?
    Broad
  14. What drug has replaced Itraconazole to a certain extent?
    Voriconazole
  15. In most situations, you can use Itraconazole as an alternative to what other antifingal?
    Amphotericin B
  16. Which fungi that are in the Amphotericin B spectrum are not in the Itraconazole spectrum?
    Mucormycosis (zygomycosis)
  17. What clinically relevant fungi can Itraconazole treat?
    Histoplasmosis, sporotrichosis, aspergillosis, blastomycosis and candidiasis
  18. Why is it hard to know if you have the right conc. Of Itraconazole?
    Absorption is sporadic
  19. Is it better to take Itraconazole with or without food?
    Without
  20. Does Itraconazole need an acidic stomach like ketoconazole to be absorbed?
    Yes
  21. Does Itraconazole enter the CNS?
    No
  22. Which is more selective for fungal enzymes, Itraconazole or ketoconazole?
    Itraconazole
  23. Does Itraconazole have endocrine side effect slike ketoconazole?
    No, if any they are minimal
  24. What are the adverse effects of Itraconazole?
    N/V, hepatotoxicity, cardiosupression, hypokalemia and rash
  25. Is Itraconazole teratogenic?
    No
  26. Can Itraconazole cause Stevens-Johnson syndrome ?
    Yes
  27. What group of patients is Itraconazole contraindindicated in due to cardiosupression?
    Patients with ventricular dysfunction
  28. Does Itraconazole inhibit CYP450?
    Yes, strong inhibitor of CYP3A4
  29. Because Itraconazole inhibits CYP3A4, what drugs should it not be administered with as it increases their concentrations?
    Cyclosporine, Lovastatin and Simvastatin
  30. A person who recently had an organ transplant is or is not a good candidate for Itraconazole use?
    If they are on the immunosuppressant Cyclosporine, then No (CYP3A4 met. Drug)

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