Neurochemistry Chapter 1
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All psychoactive drugs either directly or indirectly affect which neurotransmitter?
- Neurotransmitters that open the gate, thus increasing cell firings, are
Those that close the gate and reduce cell firings are called
Where neurotransmitters combine or attach
Strength of attraction the bind- in regards to a receptor site
Goodness of fit with the site- in regards to a receptor site
How the drugs, body (brain) and genes interact
What the body does to the drug
What the drug does to the brain/body
- Sedatives- Hypnotics
All Arounders (Psychedelics)
What is tolerance?
Effect of a given does diminishes over time
Higher and more frequent doses are needed to maintain the same effect
- (ALCOHOL) WILL RESULT IN TOLERANCE TO OTHER SIMILAR DRUGS
Abrupt discontinuation of psychoactive drug results in physical and/or psychological impairment which is relieved by the same or similar drug
Ability of one drug to suppress withdrawal symptoms of a different drug
All of those specific and individual factors about a person which mat effect the response to a drug.
Ex: personality, expectations, motivation state of health, ect
AKA what the body does to the drug
Disintegration (the process of coming to pieces ) of dosage form or dissolution of particles
- Different methods
Is the fastest method because the lugs have such a large surface area
The heart only has to beat once for some of the drug to reach the brain. (High within 7-10 Seconds)
More intense high even thought it takes a few seconds loner to reach the brain
Holding in the mouth
- Swallowing- has to reach the intestine
- Takes 10-30 minutes to get high
- On the skin
- Takes hours to get high
What is the target of the psychoactive drug?
Psychoactive drugs are fat soluble by definition
Blood Brain Barrier
Specialized cells help to create a fatty barrier of water-soluble substance.
Brain gets extra protection
Psychoactive drugs are lipid-soluble and can cross easily
The Reward System of the Brain
- Part most responsible for addiction
- Nucleus Accumbens
- Ventral Tegmental Area
Enzymes in the liver chemically alter the drug before it is ultimately eliminated fro the body
The length of time it takes for drug's concentration in the blood to be reduce by 50%
What would you like to do?
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