Skeletal Muscle Relaxants

Card Set Information

Author:
sdespins
ID:
260054
Filename:
Skeletal Muscle Relaxants
Updated:
2014-02-03 19:44:02
Tags:
Skeletal Muscle Relaxants
Folders:
Pharmacology
Description:
Drugs
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  1. Non-Depolarizing Neuromuscular Blocker

    Does not cause release of histamine

    Bind to nicotinic receptors on skeletal
    muscle at the motor end plate

    Inhibit binding of acetylcholine to
    nicotinic receptors competitively

    Prevent muscle cell membrane
    depolarization and block muscle contraction
    Cisatracurium
  2. Non-Depolarizing Neuromuscular Blocker

    Releases Histamine
    Mivacurium
  3. Non-Depolarizing Neuromuscular Blocker

    Vagolytic and causes moderate tachycardia
    Pancuronium
  4. Non-depolarizing Neuromuscular Blocker

    Most rapid onset of action and is useful for rapid tracheal intubation
    Rocuronium
  5. Non-depolarizing Neuromuscular Blocker

    Causes histamine release and ganglionic blockade
    Tubocurarine
  6. Depolarizing Neuromuscular Blocking Agent

    Is an ACh analog and binds to nicotinic receptors at motor end plate, causing membrane depolarization

    Is insensitive to acetylcholinesterase and persists at high concentrations in synaptic cleft

    Prolonged depolarization of muscle cell membrane causes muscle paralysis

    Two phases of blockade: phase I and II

    Plasma cholinesterase is butyrylcholinesterase
    Succinylcholine
  7. Spasmolytic Drug: Direct-Acting

    Used to treat Malignant Hyperthermia

    Blocks ACh from storage vesicles and inhibits neuromuscular transmission

    Treatment of local muscle spasm
    Botulinum Toxin
  8. Spasmolytic Drug: Direct-Acting

    Used to treat Malignant Hyperthermia
    Dantrolene
  9. Centrally Acting Spasmolytic Drug

    GABAReceptor Agonist


    Intrathecal administration
    Baclofen
  10. Centrally Acting Spasmolytic Drug

    Binds to GABAreceptor

    Used to treat chronic spasm due to cerebral palsy, stroke, and spinal cord injury
    Diazepam
  11. Increases release of GABA

    Also effective as a spasmolytic agent in patients with multiple sclerosis
    Gabapentin
  12. Centrally Acting Spasmolytic Drug

    Alpha-2 adrenoceptor agonist: activated by norepinephrine but when activated decreases the release of norepinephrine from the neuron

    Metabolized by P450 enzyme (CYP1A2)
    Tizanidine
  13. Centrally Acting Spasmolytic Drug

    Used for acute local muscle spasm
    Cyclobenzaprine and Metaxalone

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