Pharmacology - Antimicrobials Antivirals Anticancer drugs

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jonas112
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260392
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Pharmacology - Antimicrobials Antivirals Anticancer drugs
Updated:
2014-02-05 15:17:27
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Pharmacology Antimicrobials Antivirals Anticancer drugs
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Pharmacology - Antimicrobials, Antivirals, Anticancer drugs
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  1. Which types of Abx are excellent for gram positive infections
    • 1. Attack cell walls
    •   -beta-lactams
    •       -aminopenicillins + beta lactamase inhib.
    •       -ES penicicillins + beta lacatamase inhib
    •   -Carbapenems
    •   -vancomycin
    •   -daptomycin
    • 2. Block protein production
    •   -Streptogramins
    •   -linezolid
  2. Which types of Abx are excellent for gram negative infections?
    • 1. Attack cell walls
    •   -ES penicillin + beta lactamase inhibitors
    •   -3rd and 4th gen cephalosporins
    •   -carbapenems
    •   -monobactams (Aztreonam)
    • 2. Block protein productions
    •   -aminoglycosides: Streptomycin, gentamycin, tobramycin
    • 3. Target DNA and replication
    •   -quinolones: ciprofloxacin, moxifloxacin
  3. Which types of Abx are excellent for anaerobic infections?
    • 1. Attack cell walls
    •   -beta-lactams
    •      -aminopenicillins + beta-lactamase inhib
    •      -ES penicillins + beta-lactamase inhib
    •   -carbapenems
    • 2. Target DNA and replication
    •   - metronidazole
  4. Which types of Abx are excellent for atypical bacterial infections
    • 1. Block protein production
    •   -tetracyclines
    • 2. Target DNA and replication
    •   -quinolones: cipro, moxi
  5. Name 4 atypical bacterial incfections
    • -Chlamydia spp.
    • -Mycoplasma spp.
    • -Legionella
    • -Rickettsia
  6. What is the treatment for Hep B (acute and chronic)?
    • acute: no effective therapy
    • chronic: IFN-alpha OR lamivudine
  7. What is the treatment for Hep C?
    IFN-alpha with ribavirin
  8. What would you use to treat respiratory virus infections?
    • 1. neuramidase inhibitors: Oseltamvir and zanamivir
    • 2. viral uncoating inhibitors: amantadine and rimantadine
    • 3. drugs that screw with viral DNA: ribaviron (a guanosine analog)
  9. What would you use to treat Herpes Infection
    • 1. Drugs that screw with viral DNA:
    •   -acyclovir (valacyclovir and famciclovir are basically the same)
    •   -gancilcovir (good for CMV too)
    •   -Foscarnet
  10. Describe the 5 classes of drugs used in HIV treatment
    • 1. Nucleoside and nucleotide reverse transcriptase inhibitors
    • 2. Non-nucleoside reverse transcriptase inhibitors
    • 3. Protease inhibitors
    • 4. Viral entry inhibitors
    • 5. Integrase inhibitors

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