Pharmacology Chapter 10

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servinggod247
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260452
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Pharmacology Chapter 10
Updated:
2014-02-05 17:45:51
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pharmacology exam
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pharmacology exam 1
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  1. There is a ___________ therapeutic index on drugs for HIV for children
    narrow
  2. HIV infected women should not
    breastfeed
  3. what is used to prevent maternal transmission of HIV to fetus?
    AZT
  4. HIV replication can be ______ but not ______
    controled

    cured


  5. Influenza
    Protoype: rimantadine (Flumadine)
    • MOA:  prevents shedding of the outer viral coat of the virus
    •  
    • Caution: People who have renal disease may have sensitivity
    •  
    • Adverse effects: Orthostatic hypotension, insomnia, dizziness, urinary retension
    •  
    • Must be given early in course for treatment to be effective with 24-48 hours of symptoms
  6. Herpes/Cytomegalovirus
    Prototype: acyclovir (Zovirax)
    • MOA:  affects DNA replication
    •  
    • Caution:  can’t use in pregnancy or lactation, caution with renal disease, at best safety in children not established- at worst carcinogenic
    •  
    • Adverse:  N/V, HA, depression, rash, hair loss
    •  
    • Might be given to prevent outbreak

  7. _____ is an antigen on the surface of T helper cells that is the primary receptor for HIV which results in HIV primarily infecting _____ positive T helper lymphocytes.  
    CD4
  8. Highly Active Antiretroviral Therapy (HAART)
    uses atleast 3 drugs

  9. Adverse effects of HAART drugs:
    • Adverse effects of these medications:
    • Lipid disorders- elevate cholesterol
    • Increased risk of diabetes
    • Increased cardiovascular diseases
    • Increased risk of osteoporosis
    • At risk for nephrotoxicity
    • *Multiple drug interactions
  10. Atripla is what
    most common first line therapy for HIV. Has 3 drugs in it

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