Etomidate Midazolam Succicoline

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Author:
readyreg29
ID:
260661
Filename:
Etomidate Midazolam Succicoline
Updated:
2014-02-09 13:08:01
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Etomidate Midazolam Succicoline
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Etomidate,Midazolam,Succicoline
Description:
MEDIC 2013
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  1. ETOMIDATE
    • ETOMIDATE
    • CLASS: Sedative/hypnotic agent
  2. ETOMIDATE
    Mechanism of Action:
    • Produces hypnosis rapidly 
    • CNS depression and anesthesia
  3. ETOMIDATE
    Indications:
    Induction of anesthesia for rapid sequence intubation (RSI)
  4. ETOMIDATE 
    Contraindications:
    Hypersensitivity
  5. ETOMIDATE
    Adverse Reactions:
    • Transient muscle movements
    • Apnea
    • Minimal suppression of cortisol levels
    • Myoclonus and tremors resembling seizures
  6. ETOMIDATE
    Route of Administration:
    Adult Dosage:
    IV: 0.3 mg/kg over 30-60 seconds
  7. ETOMIDATE
    Onset of Action:
    Duration of Action:
    • Onset of Action: 1 minute
    • Duration of Action: 3-5 minutes
  8. ETOMIDATE
    Dosage Forms/Packaging:
    • 40 mg/20 mL prefilled syringe or vials
  9. SUCCINYLCHOLINE
    CLASS: Ultra-short-acting depolarizing-type skeletal muscle relaxant
  10. SUCCINYLCHOLINE
    Mechanism of Action:
    Combines with cholinergic (parasympathetic) receptors of the motor end plate to produce depolarization

    Hydrolyzed by acetylcholinesterase
  11. SUCCINYLCHOLINE
    Indications and Field Use:
    Endotracheal intubation requiring paralysis (RSI)
  12. SUCCINYLCHOLINE
    Contraindications:
    • Muscle disorders
    • History of malignant hyperthermia
    • History of hyperkalemia
    • Burn injured patients*
    • Ocular injuries (eyes)
    • Patients in whom successful endotracheal intubation is doubtful
  13. SUCCINYLCHOLINE
    Adverse Reactions:
    • Vagal stimulation leading to bradycardia or asystole
    • Hyperkalemia (>potassium) 
    • Rhabdomyolysis
    • Hypersalivation
    • Elevated intraocular pressure
    • Release of histamine
  14. SUCCINYLCHOLINE
    Route of Administration: 
    Adult Dosage:
    IV: 1.5 mg/kg repeat in 2-3 mins to achieve paralysis
  15. SUCCINYLCHOLINE
    Onset of Action:
    Duration of Action:
    Onset of Action: <1 minute

    Duration of Action: Muscle paralysis lasting 4-6 minutes
  16. SUCCINYLCHOLINE
    Dosage Forms/Packaging:
    • 200 mg/10 mL vials
  17. A disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions when the affected person gets general anesthesia
    Malignant hyperthermia
  18. MIDAZOLAM HYDROCHLORIDE
    • BRAND NAME: VERSED
    • CLASS: Central nervous system depressant Benzodiazepine
  19. MIDAZOLAM HYDROCHLORIDE
    Indications
    • Anti-convulsant
    • Sedation
    • Induction for intubation 
    • Management of acute agitation/excited delirium
  20. MIDAZOLAM HYDROCHLORIDE
    MOA
    • Produces anxiolytic, sedative, hypnotic, and anticonvulsant effects
    • (through the limbic, thalamic, and hypothalamic levels of the CNS)

    Can Produce CNS depression, from mild sedation to coma
  21. MIDAZOLAM HYDROCHLORIDE
    Contraindications:
    • Hypersensitivity 
    • Neuromuscular disorders
    • Acute alcohol intoxication
    • Severe, chronic obstructive pulmonary disease
    • Acute pulmonary insufficiency
    • Pregnancy
  22. MIDAZOLAM HYDROCHLORIDE
    Adverse Reactions:
    • Hypotension
    • Hypertension
    • Cardiac arrest
    • Respiratory depression 
    • Anxiety / Irritability
  23. MIDAZOLAM HYDROCHLORIDE
    Adult Dosage:
    Patients 14 to 60 years of age:
    • Patients 14 to 60 years of age:
    • IM: 2 to 5mg
    • IV:1-10mg no more than 2.5mg (2 minutes)

    • Patients over 60 years of age:
    • IM: 1 to 5mg
    • IV: 1-3.5mg no more than 1.5mg(2 minutes) 

    Total dose: Should not exceed 20 mg 
  24. MIDAZOLAM HYDROCHLORIDE
    Adult dosage
    For emergency intubation:
    • 0.1 - 0.3 mg/kg
    • Max. limit of 20 mg.
  25. MIDAZOLAM HYDROCHLORIDE
    Adult dosage
    Seizures:
    • IM: 0.2 mg/kg
    • IN: 0.3mg/kg  status seizures if no IV/IO access
  26. MIDAZOLAM HYDROCHLORIDE
    Onset of Action:
    Peak Effects:
    Duration of Action:
    • Onset of Action: IM - 15 minutes
    •                        IV/IO - immediate 
    • Peak Effects: IM - 15 to 60 minutes
    •                     IV - 3 to 5 minutes
    • Duration of Action: 2 to 6 hours
  27. MIDAZOLAM HYDROCHLORIDE
    Dosage Forms/Packaging:
    • 1 mg/1 mL: 5 mL vials (5 mg)

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