5.8 Pharmacology for Asthma and COPD

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Author:
xangxelax
ID:
260764
Filename:
5.8 Pharmacology for Asthma and COPD
Updated:
2014-02-07 19:10:31
Tags:
CP2
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CP2
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CP2
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  1. Explain the physiological actions of medications used to treat asthma
    • Open airways, facilitate breathing
    • Decrease/ prevent exposure to allergens and bronchial hyperresponsiveness (BHR)
    • Decrease/ prevent airway remodeling
  2. What is the MOA for Short Acting Beta-2 agonists?
    • Binds to and stimulates B-2 receptors in bronchiolar smooth muscle
    • Blocks bronchoconstriction caused by histamine, methacholine, and exercise
  3. What is the MOA for Long Acting Beta-2 agonists?
    • Binds to and stimulates B-2 receptors in bronchiolar smooth muscle
    • Blocks bronchoconstriction caused by histamine, methacholine, and exercise
    • Long acting due to binding properties
    • Lipid soluble (albuterol is more water soluble) - allows better partitioning into cell membrane which allows it to stay in the lung tissue longer and produce longer effects
  4. What is the MOA for Anticholinergics?
    • Acetylcholine stimulation of muscarinic receptors in the bronchial smooth muscle produces bronchoconstriction and mucous secretion
    • Anticholinergics block this action, maintaining bronchomotor tone
  5. What is the MOA for Corticosteroids?
    • Block the allergic response to allergens by inhibiting the release of pro-inflammatory mediators from cells
    • Histamine, Leukotrienes, Cytokines, Prostaglandins, Bradykinin
  6. What is the MOA for Leukotriene modifiers?
  7. What is the MOA for Methylxanthines?
    Theophylline is a non-selective inhibitor of phsophodiesterase which increases cAMP and cGMP
  8. What are the adverse effects for respiratory drugs?

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