5.8 Pharmacology for Asthma and COPD

  1. Explain the physiological actions of medications used to treat asthma
    • Open airways, facilitate breathing
    • Decrease/ prevent exposure to allergens and bronchial hyperresponsiveness (BHR)
    • Decrease/ prevent airway remodeling
  2. What is the MOA for Short Acting Beta-2 agonists?
    • Binds to and stimulates B-2 receptors in bronchiolar smooth muscle
    • Blocks bronchoconstriction caused by histamine, methacholine, and exercise
  3. What is the MOA for Long Acting Beta-2 agonists?
    • Binds to and stimulates B-2 receptors in bronchiolar smooth muscle
    • Blocks bronchoconstriction caused by histamine, methacholine, and exercise
    • Long acting due to binding properties
    • Lipid soluble (albuterol is more water soluble) - allows better partitioning into cell membrane which allows it to stay in the lung tissue longer and produce longer effects
  4. What is the MOA for Anticholinergics?
    • Acetylcholine stimulation of muscarinic receptors in the bronchial smooth muscle produces bronchoconstriction and mucous secretion
    • Anticholinergics block this action, maintaining bronchomotor tone
  5. What is the MOA for Corticosteroids?
    • Block the allergic response to allergens by inhibiting the release of pro-inflammatory mediators from cells
    • Histamine, Leukotrienes, Cytokines, Prostaglandins, Bradykinin
  6. What is the MOA for Leukotriene modifiers?
  7. What is the MOA for Methylxanthines?
    Theophylline is a non-selective inhibitor of phsophodiesterase which increases cAMP and cGMP
  8. What are the adverse effects for respiratory drugs?
Author
xangxelax
ID
260764
Card Set
5.8 Pharmacology for Asthma and COPD
Description
CP2
Updated