Therapeutics: VTE

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Author:
kyleannkelsey
ID:
261065
Filename:
Therapeutics: VTE
Updated:
2014-05-06 15:56:42
Tags:
VTE
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VTE
Description:
Therapeutics: VTE
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  1. Of the anticoagulants discussed, Which are SQ?
    • UFH (prophylactic dosing)
    • Enoxaparin
    • Daltaparin
    • Tinazaparin
    • Fondaparinux
  2. Of the anticoagulants discussed, Which are IV?
    UFH (treatment dosing)
  3. Of the anticoagulants discussed, which are Oral?
    Rivaroxaban and Warfarin
  4. Which anticoagulant should you bridge with Warfarin in the evening?
    Fonduparinux
  5. Which anticoagulants have a black box warning for spinal or epidural puncture leading to Hematoma?
    • Enoxaparin
    • Dalteparin
    • Fonduparinux and Rivaroxaban (UFH maybe?)
  6. Which anticoagulant should only be given for treatment of VTE in Cancer patients?
    Dalteparin
  7. Which anticoagulant should not be bridged with Warfarin?
    Dalteparin and Rivaroxaban
  8. What is the trade name for Dalteparin?
    Fragmin
  9. What is the brand name for Fragmin?
    Dalteparin
  10. What is the trade name for Fondaparinux?
    Arixtra
  11. What is the brand name for Arixtra?
    Fondaparinux
  12. What is the trade name for Rivaroxaban?
    Xarelto
  13. What is the brand name for Xarelto?
    Rivaroxaban
  14. What should you monitor for prophylactic anticoagulant use?
    • S/S of bleeds
    • Adverse events
    • Pain/irritation/bruising at injection site
    • Complete CBC Periodically
  15. Can you bridge Enoxaparin with Warfarin?
    Yes
  16. Rivaroxaban is metabolized by what enzymes?
    • CYP3A4
    • CYP2J2
    • CYP3A5 and P-gp
  17. What drugs are contraindicated with Rivaroxaban?
    CYP: 

    • Ketoconazole
    • Protease inhibitors
    • Phenytoin
    • Clarithromycin
    • Erythromycin

    P-gp:

    • Rifampin
    • Carbemazapine

    Other:

    Antiplatelets/NSAIDs and St. Johns Wort
  18. Can you use Warfarin during pregnancy?
    No
  19. What is the pregnancy category for Rivaroxaban?
    C
  20. What is the risk factors for Provoked VTE?
    • Surgery
    • immobilization
    • pregnancy
    • oral contraceptives
  21. Rivaroxaban was found to be more efficacious than Enoxaparin in what situation?
    Following total knee or Hip replacement
  22. Why should you cautiously use Rivaroxaban in patients over 75?
    Diminished renal function
  23. What is the trade name for Innohep?
    Tinazaparin
  24. What is the brand name for Tinazaparin?
    Innohep
  25. Is Rivaroxaban safe for lactating mothers?
    • No known
    • Use with caution
  26. Which anticoagulants should be given in Combo with Warfarin in the treatment of VTE?
    Enoxaparin, Tinazeparin, Fonduparinux, UFH

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