What is a transmembrane enzyme receptor? What are the characteristics? Give an example.
It is a membrane receptor that has a cytoplasmic catalytic domain.
An example is a tyrosine kinase receptor. They are receptors for growth factors and tranduce their signals from them. The Growth factors (ligands) attach to an inactive, unliganded, tyrosine kinase receptor, which is a monomer.
When the growth factor binds to the binding site, two tyrosine kinase receptors that are next to each other join and they form a functional unit - a diamer.
- This diamerization a causes an
- autophosphorilation of tyrosine residues.
Now the diamer is active. Through an adaptor, they activate the effector