micro ch 6
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what are some characteristics of ideal antimicrobial drug?
- microbicidal and not microbistatic
- soluble, penetrate through
- potent long enough
- not subject to antimicrobial resistance
- assists activities of host defense
- remains active in tissues
- not costly
some antibacterials that inhibit cell wall synthesis
types of Beta-lactams
- clavulanic acid + amoxycillin
- sulbactam + ampicillin
- tazobactam + piperacillin
some antibacterials that inhibit protein synthesis
types of aminoglycosides
Beta-lactams are more active against gram pos or gram neg?
How can inhibitors of protein synthesis not effect us?
How do inhibitors of protein synthesis work?
- mRNA is misread
- peptide bond is blocked
- anticodon on tRNA is blocked (prevents initiation of protein synthesis)
What are the mechanisms of drug resistance?
- drug inactivation
- decreased permeability
- activation of drug pumps
- use of alternate metabolic pathways
choosing which drug to take:
- health status of patient
- receptor site & binding proteins
- mixture of IV
how would an antimicrobial reach the site of infection?
at inhibitory concentratoins
the antimicrobial penetrates and binds to target, avoiding what?
inactivation and extrusion
what are the for possible target sites for antibacterials?
- cell wall synthesis
- protein synthesis
- nucleic acid synthesis
- cell membrane function
dissemination related to mutant selection
dissemination related to spread of resistance plasmid
what is dissemination of resistance genes?
how resistance genes spread out throughout the area
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