Binds to calcium in teeth. May cause yellow or brown staining of teeth.
Do not use with children
May cause hypertensive response with MAO inhibitors or tyramine containing food.
Lactic acidosis- periodic checks of bicarb levels
May cause bone marrow suppression
Optic neuropathy- visual impairment
Not really antibiotic, works by inhibiting folic acid in bacteria.
Primarily used to treat UTI and otitis media (ear infection)
hepatitis, jaundice, pancreatitis
Kidney and liver toxicity
Headache, dizziness, seizures
Encourage water intake
Many are allergic to it
Ketolides "mycin" (Telithromycin)
Similar to macrolides. Used for 2nd line of defense for resistant bacteria. Especially gram + respiratory infections.
Used as alternate for PCN allergies.
Thrombophlebitis, very irritating to vein
Best given on empty stomach
Can distort taste
Many drug interactions like coumadin, theophylline, carbamepezine
Aminoglycosides "mycin or cin"
Used for gram - bacteria especially nosocomial
5. Neomycin Sulfate
Ototoxicity and kidney damage.
Do not mix gentamycin with heparin or mix with penicillins.
Very potent, reserved for resistant gram + bacteria
Side effects for Vancomycin only
Monitor IV site closely, very irritating to tissues and causes necrosis and severe pain with extravasation
Red man syndrome, infuse over 60 min.
General Side effects
Ototoxicity of inner ear
Nephrotoxic (cloudy or pink urine may be a sign of nephrotoxicity)
Peak and trough
PO, IM, IV, Vaginal, Topical
Monitor IV site closely for phlebitis
Arrhythmias, hypotension with rapid infusion
Used for intestinal superinfection with protozan from antibiotic therapy
Kills C-diff, use flagyl first before vacomycin
Unpleasant metallic taste
Darkening of urine
Elevated intracranial pressure, seizures
Used for treatment of drug resistant such as MRSA & VRSA, very potent, used ONLY if a bacteria is resistant
Assess patient for myalgia and arthralgia after infusion.
Edema, inflammation, pain at infusion site
Avoid shaking the reconstituted medication to prevent foam formation
1. Imipenem (Primaxin)
Seizures, dizziness, somnolence
may be inactivated if administered concurrently with aminoglycosides. If administered concurrently, administer in separate sites, if possible, at least 1 hr apart. If second site is unavailable, flush lines between medications.