Chem Basis - AGNs 1

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kyleannkelsey
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261425
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Chem Basis - AGNs 1
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2014-02-11 12:34:23
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Chem Basis AGNs
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Chem Basis - AGNs 1
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Chem Basis - AGNs 1
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  1. What is the spectrum of this molecule?
    • Aerobic G-
    • P. aureuginosa
    • E. Coli
    • Klebsiella
    • H. Influenzae
    • Proteus, Salmonella
    • Serratia
    • Acinitobacter
    • Enterobacter
    • (Gentimicin)

  2. Would this be a good drug to treat Neisseria?
    • No, only moderate activity when used alone
    • (Gentimicin)

  3. Would you use this drug for a severe infection like P. aeruginosa septicemia?
    • Yes, but only in combination with a broad spectrum B-lactam
    • (Gentimicin)

  4. Would you use this drug for a P. aeruginosa pneumonia infection?
    • Could, but would choose Tobramycin first because it has better lung penetration.
    • (Gentimicin)

  5. This drug was the first antibiotic with significant activity against what bacterial species?
    • E. coli
    • (Gentimicin)

  6. What are the main side effects of this drug?
    • Irreversible Oto and Vestibular toxicity and reversible renal toxicity (main side effect is renal)
    • (Gentimicin)

  7. What is the significance of this site on Gentamicin?
    • No 3”-OH on ring I
    • Phosphotransferases cannot phosphorylate

  8. What is the significance of this site on Gentamicin?
    • No 4”-OH on ring I
    • Nucleotidyltransferases cannot adenylate

  9. What is the significance of this site on Gentamicin?
    • Axial 4’-OH
    • Nucleotidyltransferases cannot adenylate

  10.  What is the significance of this site on Gentamicin?
    • 3-NH2
    • Susceptible to Acetylation by Aminoacetyltransferase

  11. What part of this molecule is involved in inactivation reactions that inactivate both itself and B-lactams?
    • Amino groups
    • (Gentamicin)

  12.  Does E. coli show any resistance to Gentimicin?
    Yes, some
  13. Under what conditions would you use Gentimicin for community acquired Pneumonia in the ICU?
    If at risk of Pseudomonas infection

  14. What is this drug?
    Neomycin

  15. By what routes can this molecule be given?
    • Oral and Topical (NOT IM/IV, very nephrotoxic)
    • (Neomycin)

  16. Is this drug absorbed in the GI?
    • No
    • (Neomycin)

  17. What is Neomycin used for orally?
    • Prevention of Hepatic encephalopathy by reducing ammonia (especially prior to GI surgery)
    • Gut sterilization prior to bowel surgery

  18. What side effect is more common with Neomycin than other Aminoglycosides?
    Hypersensitivity

  19. Is this drug susceptible to inactivation through Acetylation by Aminoacetyltransferase, why or why not?
    • Yes
    • Due to the N2 groups

  20. Is this a Diguanidine (1, 3-Diaminohexose) or a 2-Deoxystreptamine (1,3-Diaminocyclohexane)?
    • 2-Deoxystreptamine (1,3-Diaminocyclohexane)

  21. What is this molecule?
    Tobramycin

  22. By what routes can this drug be given?
    • Ophthalmic Topical
    • Injection
    • (Tobramycin)

  23. When would you give this drug as an injection?
    • Severe life-threatening G- infections
    • Meningitis in Neonates
    • PID
    • Brucillosis
    • (Tobramycin)

  24. What drug might you give this drug in combination with for topical treatment of bacterial conjunctivitis?
    Dexamethason

  25. What is the spectrum of this molecule?
    • Aerobic G-
    • P. aureuginosa
    • E. Coli
    • Klebsiella
    • H. Influenzae
    • Proteus, Salmonella
    • Serratia
    • Acinitobacter
    • Enterobacter
    • Same as Gentimicin
    • (Tobramycin)

  26. Would this be a good drug to treat Neisseria?
    • No, only moderate activity when used alone
    • (Tobramycin)

  27. Would you use this drug for a severe infection like P. aeruginosa septicemia?
    • Yes, but only in combination with a broad spectrum B-lactam
    • (Tobramycin)

  28. Would you use this drug for a P. aeruginosa pneumonia infection?
    • Yes, because it has good lung penetration.
    • (Tobramycin)

  29. What are the main side effects of this drug?
    • Irreversible Oto and Vestibular toxicity
    • (Tobramycin)

  30. What is the significance of this site on Tobramycin?
    • No 3”-OH on ring I
    • Phosphotransferases cannot phosphorylate

  31. What is the significance of this site on Tobramycin?
    • 3-NH2
    • Susceptible to Acetylation by Aminoacetyltransferase
    • (Tobramycin)

  32. Is this a Diguanidine (1, 3-Diaminohexose) or a 2-Deoxystreptamine (1,3-Diaminocyclohexane)?
    • 2-Deoxystreptamine (1,3-Diaminocyclohexane)

  33. What is this drug?
    Streptomycin

  34. Could you use this drug for an M. tuberculosis infection?
    • Yes
    • (Streptomycin)

  35. What is this drug used for?
    • In combination for:
    • Tuberculosis
    • Bubonic Plague
    • Brucellosis
    • (Streptomycin)

  36. What types of bacteria is this drug active against?
    • G+ and G-
    • (Streptomycin)

  37. Why is this drug no longer commonly used?
    • High toxicity
    • (Streptomycin)

  38. What type of toxicity is common with this drug?
    • Vestibular toxicity
    • (Streptomycin)

  39. Is this a Diguanidine (1, 3-Diaminohexose) or a 2-Deoxystreptamine (1,3-Diaminocyclohexane)?
    • Diguanidine (1, 3-Diaminohexose)
    • “1, 3-Diaminohexose”
    • (Streptomycin)

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