Chem Basis - AGNs 2

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  1. Image UploadWhat is this drug?
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    Would you use this drug to treat Mycobacterium avium?
    • You could, it has activity, but it is not a first line therapy
    • (Amikacin)
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    What are the side effects of this drug?
    • Ototoxicity
    • (Amikacin)
  4. How is Ototoxicity manifested?
    • Hearing loss
    • Tinnitus
    • Often Irreversible
  5. How is Vestibular toxicity manifested?
    • Dizziness
    • Vertigo
    • Ataxia
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    What is the significance of this group?
    • Prevents Acetylation at the 3-NH2 position by Aminoacetyltransferase
    • Provides resistance to inactivation by P. aeruginosa and M. tuberculosis that other AGs are susceptible to
    • Inhits phosphorylation of the 3”-OH (see image)
    • Inhibits adenylation of the 2’-OH (see image)
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    • (Amikacin)
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    What is this group called?
    • L-alpha-hydroxy-alpha-aminobutyric-acid (HABA)
    • (Amikacin)
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     What is the significance of this group?
    • Susceptible to acetylation by aminoacetyltransferase 
    • (Amikacin)
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    When would you use this drug?
    • Reserved for strains resistant to other AGs
    • (Amikacin)
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    Is this drug first line?
    • No
    • (Amikacin)
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    Is this a Diguanidine (1, 3-Diaminohexose) or a 2-Deoxystreptamine (1,3-Diaminocyclohexane)?
    • 2-Deoxystreptamine (1,3-Diaminocyclohexane)
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    What is this drug?
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    What is unique about the structure of this drug?
    • It is a mix of three components
    • (Kanamycin)
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    Why is this drug no longer used?
    • Resistance has developed
    • (Kanamycin)
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    Can this drug be given orally?
    • Yes
    • (Kanamycin)
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    Is this drug effective against Mycobacteria, such as M. tuberculosis?
    • Yes
    • (Kanamycin)
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    What is the significance of these 2 structures?
    • Susceptible to adenylation by Nucleotidyltransferase
    • (Kanamycin)
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    What is the significance of these 3 structures?
    • Susceptible to Acetylation by Aminoacetyltransferase
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    • (Kanamycin)
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     What is the significance of these 3 structures?
    • Susceptible to Phosphorylation by Phosphotranseferases
    • (Kanamycin)
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    Which AGS would you choose if an organism were resistant to Kanamycin?
    • Gentamicin or Tobramycin
    • Because both lack an R3”-OH
    • Gentamicin also lacks a 4”-OH
    • So, they are resistant to Phosphotraneferases, the most troubling inactivation of Kanamycin
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     Which subspecies: A, B or C is susceptible to phosphotranseferases, aminoacetyltransferases and Nucleotidyl transferases?
    • B
    • (Kanamycin)
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    Which drug is a semisynthetic Kanamycin A derivative?
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    • Amikacin
Card Set:
Chem Basis - AGNs 2
2014-02-11 19:24:51
Chem Basis AGNs
Chem Basis - AGNs 2
Chem Basis - AGNs 2
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