MSS2

Card Set Information

Author:
Anonymous
ID:
261951
Filename:
MSS2
Updated:
2014-02-13 23:49:01
Tags:
MSS
Folders:

Description:
MSS 2 -- medical school
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Anonymous on FreezingBlue Flashcards. What would you like to do?


  1. Normal melanocytic nevi gene progression RAS > BRAF > and p16/INK4a
  2. Melanoma Mutated BRAF (non RAS activation of BRAF)
  3. Benign nevus "mole" most common neoplasm of the skin?
  4. Lentigo nevus Flat
    pigmented
  5. Means benign = as in mole Maturation of the malnocytes
  6. Acral lentiginous melanoma-mets to brain/lung Melanoma in an african american (under nails)
  7. 0% chance of Mets - Depth of invasion is key Invasion less than .75 mm
  8. Superficial spreading melanoma CDKN2A mutation
  9. "excisional" biopsy Treatment for supfercial melanoma?
  10. Actinic keratosis flat
    brown erythematous
  11. Junctional nevus Benign
    round
  12. Keratoacanthoma (hiso: looks like Sq Cell Ca. ) Rapidly growing nodule that regresses
  13. Keratoacanthoma Rapidly growing
    crateriform w/ keratin plug
  14. Benign fibrous histiocytomas (Dermatofibroma ) spindle-shap fibroblasts
    brown papule on legs
  15. Epidermal inclusion cysts ('sebaceous cysts) subQ
    dermal keratin-filled cavity lined by Sq epi
  16. Stevens - Johnson syndrome (>10% of body) Vesicular lesion on skin + mouth
    after abx therapy
  17. Mycosis fungoides (sezary cells- cebriform nucli) cutaneous lymphoma wa proliferation of CD4 cells
  18. Melasma pigmentation
    blotches
  19. Psoriasis (salmon colored plques) Nphils
    munro
  20. Osteopetrosis (cant acidify - cant break down) Mutated CA2 gene
    carbonic anhydrase II.
  21. Familial Pagets (enhance nfkb activation) SQSTMl Mutation present in 40% to 50%
  22. pathognomonic for hyperparathyroidism Subperiosteal resorption
  23. Osteoma Benign admix of woben and lamellar bone
  24. Osteiod osteoma/osteoblastoma woven bone in fibrovascular matrix
  25. Osteoid osteoma osteoid and woven bone rimmed by osteoblasts
  26. osteosarcoma Periosteal elevation; onion skinning; sunburst
  27. Codmans Triangle elevated periosteum forms angle w the cortex
  28. Retinoblasatoma (RB) and p53 loss of function Genetic component of osteosarcoma
  29. Osteochondroma aka Exostosis from cortex Benign cartilage capped neoplasms of bone
  30. Ewing Sarcoma (Primative Neuroectoderm tum) Express c-myc +exhibit t(11:22)(q24;q12) 85%
  31. Ewing sarcoma Sm round nuclei w chromatin w/out nucleoli
  32. Homer-Wright rosette - Ewing Sarcoma tightly packed
    grow in a diffuse pattern;
  33. Ganglion Cysts Fibrous enclosure w/ synovial fluid
  34. Tenosynovial Giant Cell Tumor Fibroblast like cells
    multinucleate giant cells
  35. Tenosynovial Giant cell Tumor (dt hemosiderin) Pigmented Villonodular Synovitis of the knee
  36. Giant cell tumor of tendon sheath localized nodular tenosynovitis
    solid brown cast
  37. Giant cell tumor (GCT) of tendon sheath Histiocytes+multinucleated giants in fibrous tis
  38. Seborrheic keratoses Coin like
    velvety
  39. Inc risk for RB and osteosarcomas Retinoblastoma tumor suppressor mutation
  40. Xerodermal pigmentosa Cant repair pyrimidine (thy) dimers (AR dz)
  41. Necrotizing fascitits Trauma + infx w/ group a strep = crepitus
  42. Nodular melanoma - depth most important Prx Brwn-blk
    nodular lesion w irregular border
  43. Melanoma 98% pt with lesions <0.75 mm disease free @5 yr
  44. Trichophyton rubrum - jock itch - Tinea cruris erythematous
    scaling patches in crotch
  45. Tinea capitus - ring worm of the head Athlete's foot
    or Tinea pedis
  46. Dysplastic nevus syndrome 100+ macular
    raised skin lesions inc risk CA
  47. Erythema multiforme w/ target leions Follows Herpes infx
    keratinocyte apoptosis
  48. Molluscum contagiosum pox virus cuases firm nodule on trunk or genitals
  49. Pemphigus vulgaris Flacid blistering AI dz - IgG to desmosomes
  50. Dermatomyositis violaceous ('heliotrope') on upper eyelids
  51. Actinic keratoses rough
    scaling
  52. Type 1 hypersensitivy
    IgE + histamine Hives - irregular
  53. Type 4 hypersensitivity (CD4/8 mediated) contact dermatitis onset is delayed by days
  54. Skin tag (fibroepithelial polyp ) bag-like attached by a stalk. Don't regress.
  55. Bullous pemphigoid (tense bullus) type 2 HS reaction w/ IgG to hemi-desmosome
  56. Pemphigus vulgaris (flacid bullae) Type 2 HS rxn w IgG to desmoglein
  57. Dermatitis herpetiformis Type 2 HS rxn w/ IgA to tips of papilla
    celiacs
  58. Basal cell carcinoma Ulcer
    island of palisading cells at periphery
  59. Squamous cell carcinoma Shallow ulcer w/ keratin crust
    extend into dermis
  60. Keratoacanthoma Rapid growing
    keratin filled crater
  61. Seborreic keratosis Uniformly brown w/ round flat papules
    velvety
  62. Seborrheic keratosis Keratin filled horn cysts
  63. Xeroderma pigmentosum cant fix tymine dime Mult firm raised papules (CA)
    shiney waxy
  64. Folliculitis - staph aureus Painful pustules around hair follicles
  65. Shingles - Herpes zoster
    Varivella Zoster virus Painful unilateral versicular dermatomal rash
  66. Marfans - fibrillin def Tall slender vision problems
  67. Wegners Focal necrotizing vasculritis
    granuloma
  68. Xanthomas w. mutltinucleated giant cells Lipidemia w/ raised yellow papules on eye
  69. Psoriasis Munro microabscesses
    neutrophils in corified epi
  70. Dermatitis herpetiformis Microscopic blisters at dermal/epi junction
  71. Myathenia gravas Ptosis
    diplopia
  72. Vitiligo - assoc w/ hashimotis Skin depigmentation
    white patches
  73. Psorisis -parakeratosis-nuclei in strat corneum Red lesion w/ silvery scales on elbow
  74. Spongiosis - wheal lesions Edema in the epidermis
  75. hyperkeratosis Increase in the stratum corneum
  76. Skin changes dt aging and sun
    not pre-CA Liver spots
  77. White
    age
  78. Basal cell CA Nodule
    elarging
  79. Molluscum Contagiosum DNA pox virus - STD
    pearly flesh
  80. Lipoma subQ
    soft round oval mass of fatty tissue
  81. Dermatomyositis (heliotrope lid + Gotton paps) Cant comb hair nor climb stairs
    facial rash
  82. Dermatitis Herptiformis Celiac disease
    IgA
  83. Polymyalgia rheatica Mus weakness
    Giant cell arteritis
  84. Hand foot mouth disease Gray vessicles on reddended base
    hands and feet
  85. Tinea versicolor (malassezia furfur) Hypopigmented patches on chest during summer
  86. P. Acne (comedomes) Blocking of sebaceous gland along w/ infx
  87. onychomycosis Thick yellow hard to cut toe nails
  88. Melanosomes
    taken up by keratinocytes Note: melanocytes make melanin
  89. Contact dermatitis Red
    itchy patches
  90. Bullous pemphigoid Thick bullae
    IgG 2 hemidesmosomes on basemem
  91. Rocky mt spotted fever (rickettsii) Rash on hand/feet spreads to trunk
  92. Atopic dermatitis Chronic pruritic lesion w/ asthma
  93. Actinic keratoseis (sq dysplaisa precur) Dry rough pearly scale lesion
    rough preCA lesions
  94. dermatofibromas Leg lesion 2cm hard tan papules
    benign
  95. psoriasis Itchy scaly rash on elbows
    nail involvment
  96. Psoratic arthritis (10% of pts w/ psoriasis) Arthritis in spince
    seronegative
  97. Pityriasis rosea Harlald patch à xmas tree
    plaque w/ collarte scale
  98. Stasis dermatitis Scaley patch and ulceration w/ vericose veins
  99. Bullous pemphiogoid (IgG to hemidesmosomes) Urticarial
    papular
  100. Rosacea Erythemia
    telangictasia
  101. Koebner phenomenon (seen in psorasis) Skin lesions appear on lines of trauma
  102. Auspitz sign (psoriasis) Appearance blood spots after scale removal
  103. Gottrons papules Purple papules on figers w/ dermatomyositis
  104. Dariers Sign (wheals allergic dermatitis) Allergic pts develop urticaria when skin rubbed
  105. Dermatomyosits w/ guttrons papules Anti-Jo1 autoantibody - violet flat top lesion
  106. Dermatitis Herpetiformis IgA antibody
    celiacs disease
  107. Erythema multiforme Viral hepatitis associated with target lesions
  108. Imptigo - staph aruea (cat / coagulase pos) Honey crusted pyogenic infx
    purulent
  109. Lichen Planus - assoc w/ chronic hep c virus Pruritic planar purple papules
    saw tooth histo
  110. Necrotizing Fascitits Group A strep 2nd to Varicella infx
  111. Stevens johnson (>10% of body) Bullous erthyema multiforme
    mucus membranes
  112. Toxic epidermal necolysis Severe SJS (slough + bullus) w/ >30% of body
  113. Superfial spreading melanoma Melanoma: plaques w/ blue-black spots
  114. Nodular melanoma Melanoma: rapid growing dark papule
  115. Lentigo meligna melanoma Melanoma: Brown macule on sen exposed face
  116. Acral lentiginous melanomas Melanoma: AA on palms feet toe
  117. Basal cell CA (may effect eye) Shiny pearly nodule or ulcerated nodule on eyelid
  118. Squamous cell CA Red papule or crusted on lower lip
  119. Gouty arthtis Swelling
    deformity and joint destruction
  120. Reumatoid arthtis small joints
    pannus marked joint deformity.
  121. Degenerative osteoarthritis erosion and loss of articular cartilage osteophytes
  122. Osteomyelitis infection that produces marked bone deformity
  123. Pseudogout Rhoboid cyrstals
    blue biferigence calcium pyrophs
  124. Osteomalacia lacking in vitamin D
    clinically same as osteoporosis
  125. Osteogenesis imperfecta inherited disorder of type 1 collagen synthesis
  126. chondrosarcoma Hip pain w/ blue white cut surface
  127. Osteosarcoma most frequent primary malignancy of bone
  128. osteosarcomas associated with Paget disease of bone
  129. Ewing sarcoma t(11:22) 'small round blue cell' tumor of bone in kids
  130. Salmonella African w/ sickle cell and back pain (osteomyelitis)
  131. Pagets dz of the bone (risk for cardiac failure) Sclerosis
    hats don't fit
  132. occur in the metaphyseal region Osteosarcomas.
  133. diaphysis Ewing sarcoma
  134. Prostate Ca Mets cuase Osteoblastic lesions in spine
  135. Mult Myoloma (monoclonal IG w/ plasma cells) Mets cuase osteolytic lesions (+bence jones)
  136. Osteosarcoma Atypical long cell w hyperchromatic nuclei n osteoid
  137. Osteosarcoma (codmans) metaphysis mass eroding cortex
    lifts periosteum
  138. Osteoporosis Complication of long-term corticosteroids use
  139. Rickets/Osteomalacia Def of vitamin D in kids/adults with growing bones.
  140. Osteochondroma Lateral projection
    metaphyseal region of his femur
  141. Giant cell tumor Reactive multinculeated giants
    in epiphysis
  142. Osteoid osteoma small nidus is surrounded by sclerotic bone
  143. Endochondroma -Ollier dz (many of them) Benign cartilage tumor of hands and feet
  144. Paget dz of bone (complication = heart failure) mosaic ostiod w both increased Blast/Clast activity
  145. Osteitis fibrosa cystica 'brown tumor'hyperparathyroidism
  146. Neisseria gonorrheae infection 20 male acute artiths
    w/ neutrophils
  147. Osteogensis imperfecta (def in type1 collagen) Blue sclerae
    hearing loss
  148. Osteopetrosis (dt carbonic anhydrase def) (AD) Defect in osteoclasts w thickened
    sclerotic bone
  149. Achondroplasia (bad endochondrial bone form) Dwarfism dt mutated EGFR3
  150. Autosomal dominant OI type II
    the perinatal lethal form
  151. Inc risk for osteosarcoma Retinoblastoma mutation
  152. achondroplasia Fibroblast growth factor receptor 3
  153. ankylosing spondylitis HLA-B27 ipositive in which spine lesions
  154. Osteoid osteoma (pain releived by asprin) Nidus covered by sclerosis
    release prostaglandins
  155. Hyperparathryoidism = osteitis fibrosa cystica Patient in Renal Failure (BUN/Creatine)
  156. Giant cell tumor of bone epiphyseal of femur with a "soap bubble"
  157. Osteosarcoma Metaphyseal
    destroys cortex
  158. Chondrosarcomas chondrocytes with cartilagenous matrix
  159. Ewing Sarcoma (Onion skin) t11:22 Small round blue cells of primitive neuroectoderm
  160. osteosarcoma Osteoid production by a malignant bone neoplasm
  161. RA complication - rheumatoid nodule granulomatous inflammation seen in soft tissues
  162. Osteoarthritis Cartilage erosion
    subchondral sclerosis
  163. Osteosarcomas malignant spindle cells within an osteoid matrix.
  164. Duchenne muscular dystrophy (xlink recssive) fibrosis w atrophy of fibers pseudohypertrophy
  165. Myotonic dystrophy is an (AD) disease cataracts
    bald
  166. Polymyositis-dermatomyositis Jo-1 antibody mediated by cytotoxic CD8 Tcells
  167. Duchenne muscular dystrophy lack of dystrophin staining
  168. Becker muscular dystrophy. Reduced Dystrophin staining
  169. Myotonic dystrophy (AD) w/ ring fibers CTG repeats in a gene for myotonin protein kinase
  170. Lambert-Eaton syndrome Auto antibodies to presynaptic Ca++ channels
  171. Dermatomyositis HLA-DR3 phenotype
    skin rash
  172. Urticaria Pigmentosa Mastocytosis in children
    widespread papules and small plaques
  173. Type 1 Hypersensitivity (urticaria
    angioedema) IgE antibody binding to exogenous antigen
  174. Type 2/3 HST (pemphigus vulgaris
    bullous pemphigoid) IgG/IgM antibody to cell surface antigen
  175. Normal melanocytic nevi gene progression
    RAS > BRAF > and p16/INK4a
  176. Melanoma
    Mutated BRAF (non RAS activation of BRAF)
  177. Benign nevus "mole"
    most common neoplasm of the skin?
  178. Lentigo nevus
    Flat
  179. Means benign = as in mole
    Maturation of the malnocytes
  180. Acral lentiginous melanoma-mets to brain/lung
    Melanoma in an african american (under nails)
  181. 0% chance of Mets - Depth of invasion is key
    Invasion less than .75 mm
  182. Superficial spreading melanoma
    CDKN2A mutation
  183. "excisional" biopsy
    Treatment for supfercial melanoma?
  184. Actinic keratosis
    flat
  185. Junctional nevus
    Benign
  186. Keratoacanthoma (hiso: looks like Sq Cell Ca. )
    Rapidly growing nodule that regresses
  187. Keratoacanthoma
    Rapidly growing
  188. Benign fibrous histiocytomas (Dermatofibroma )
    spindle-shap fibroblasts
  189. Epidermal inclusion cysts ('sebaceous cysts)
    subQ
  190. Stevens - Johnson syndrome (>10% of body)
    Vesicular lesion on skin + mouth
  191. Mycosis fungoides (sezary cells- cebriform nucli)
    cutaneous lymphoma wa proliferation of CD4 cells
  192. Melasma
    pigmentation
  193. Psoriasis (salmon colored plques)
    Nphils
  194. Osteopetrosis (cant acidify - cant break down)
    Mutated CA2 gene
  195. Familial Pagets (enhance nfkb activation)
    SQSTMl Mutation present in 40% to 50%
  196. pathognomonic for hyperparathyroidism
    Subperiosteal resorption
  197. Osteoma
    Benign admix of woben and lamellar bone
  198. Osteiod osteoma/osteoblastoma
    woven bone in fibrovascular matrix
  199. Osteoid osteoma
    osteoid and woven bone rimmed by osteoblasts
  200. osteosarcoma
    Periosteal elevation; onion skinning; sunburst
  201. Codmans Triangle
    elevated periosteum forms angle w the cortex
  202. Retinoblasatoma (RB) and p53 loss of function
    Genetic component of osteosarcoma
  203. Osteochondroma aka Exostosis from cortex
    Benign cartilage capped neoplasms of bone
  204. Ewing Sarcoma (Primative Neuroectoderm tum)
    Express c-myc +exhibit t(11:22)(q24;q12) 85%
  205. Ewing sarcoma
    Sm round nuclei w chromatin w/out nucleoli
  206. Homer-Wright rosette - Ewing Sarcoma
    tightly packed
  207. Ganglion Cysts
    Fibrous enclosure w/ synovial fluid
  208. Tenosynovial Giant Cell Tumor
    Fibroblast like cells
  209. Tenosynovial Giant cell Tumor (dt hemosiderin)
    Pigmented Villonodular Synovitis of the knee
  210. Giant cell tumor of tendon sheath
    localized nodular tenosynovitis
  211. Giant cell tumor (GCT) of tendon sheath
    Histiocytes+multinucleated giants in fibrous tis
  212. Seborrheic keratoses
    Coin like
  213. Inc risk for RB and osteosarcomas
    Retinoblastoma tumor suppressor mutation
  214. Xerodermal pigmentosa
    Cant repair pyrimidine (thy) dimers (AR dz)
  215. Necrotizing fascitits
    Trauma + infx w/ group a strep = crepitus
  216. Nodular melanoma - depth most important Prx
    Brwn-blk
  217. Melanoma
    98% pt with lesions <0.75 mm disease free @5 yr
  218. Trichophyton rubrum - jock itch - Tinea cruris
    erythematous
  219. Tinea capitus - ring worm of the head
    Athlete's foot
  220. Dysplastic nevus syndrome
    100+ macular
  221. Erythema multiforme w/ target leions
    Follows Herpes infx
  222. Molluscum contagiosum
    pox virus cuases firm nodule on trunk or genitals
  223. Pemphigus vulgaris
    Flacid blistering AI dz - IgG to desmosomes
  224. Dermatomyositis
    violaceous ('heliotrope') on upper eyelids
  225. Actinic keratoses
    rough
  226. Type 1 hypersensitivy
    IgE + histamine
  227. Type 4 hypersensitivity (CD4/8 mediated)
    contact dermatitis onset is delayed by days
  228. Skin tag (fibroepithelial polyp )
    bag-like attached by a stalk. Don't regress.
  229. Bullous pemphigoid (tense bullus)
    type 2 HS reaction w/ IgG to hemi-desmosome
  230. Pemphigus vulgaris (flacid bullae)
    Type 2 HS rxn w IgG to desmoglein
  231. Dermatitis herpetiformis
    Type 2 HS rxn w/ IgA to tips of papilla
  232. Basal cell carcinoma
    Ulcer
  233. Squamous cell carcinoma
    Shallow ulcer w/ keratin crust
  234. Keratoacanthoma
    Rapid growing
  235. Seborreic keratosis
    Uniformly brown w/ round flat papules
  236. Seborrheic keratosis
    Keratin filled horn cysts
  237. Xeroderma pigmentosum cant fix tymine dime
    Mult firm raised papules (CA)
  238. Folliculitis - staph aureus
    Painful pustules around hair follicles
  239. Shingles - Herpes zoster
    Varivella Zoster virus
  240. Marfans - fibrillin def
    Tall slender vision problems
  241. Wegners
    Focal necrotizing vasculritis
  242. Xanthomas w. mutltinucleated giant cells
    Lipidemia w/ raised yellow papules on eye
  243. Psoriasis
    Munro microabscesses
  244. Dermatitis herpetiformis
    Microscopic blisters at dermal/epi junction
  245. Myathenia gravas
    Ptosis
  246. Vitiligo - assoc w/ hashimotis
    Skin depigmentation
  247. Psorisis -parakeratosis-nuclei in strat corneum
    Red lesion w/ silvery scales on elbow
  248. Spongiosis - wheal lesions
    Edema in the epidermis
  249. hyperkeratosis
    Increase in the stratum corneum
  250. Skin changes dt aging and sun
    not pre-CA
  251. White
    age
  252. Basal cell CA
    Nodule
  253. Molluscum Contagiosum
    DNA pox virus - STD
  254. Lipoma
    subQ
  255. Dermatomyositis (heliotrope lid + Gotton paps)
    Cant comb hair nor climb stairs
  256. Dermatitis Herptiformis
    Celiac disease
  257. Polymyalgia rheatica
    Mus weakness
  258. Hand foot mouth disease
    Gray vessicles on reddended base
  259. Tinea versicolor (malassezia furfur)
    Hypopigmented patches on chest during summer
  260. P. Acne (comedomes)
    Blocking of sebaceous gland along w/ infx
  261. onychomycosis
    Thick yellow hard to cut toe nails
  262. Melanosomes
    taken up by keratinocytes
  263. Contact dermatitis
    Red
  264. Bullous pemphigoid
    Thick bullae
  265. Rocky mt spotted fever (rickettsii)
    Rash on hand/feet spreads to trunk
  266. Atopic dermatitis
    Chronic pruritic lesion w/ asthma
  267. Actinic keratoseis (sq dysplaisa precur)
    Dry rough pearly scale lesion
  268. dermatofibromas
    Leg lesion 2cm hard tan papules
  269. psoriasis
    Itchy scaly rash on elbows
  270. Psoratic arthritis (10% of pts w/ psoriasis)
    Arthritis in spince
  271. Pityriasis rosea
    Harlald patch à xmas tree
  272. Stasis dermatitis
    Scaley patch and ulceration w/ vericose veins
  273. Bullous pemphiogoid (IgG to hemidesmosomes)
    Urticarial
  274. Rosacea
    Erythemia
  275. Koebner phenomenon (seen in psorasis)
    Skin lesions appear on lines of trauma
  276. Auspitz sign (psoriasis)
    Appearance blood spots after scale removal
  277. Gottrons papules
    Purple papules on figers w/ dermatomyositis
  278. Dariers Sign (wheals allergic dermatitis)
    Allergic pts develop urticaria when skin rubbed
  279. Dermatomyosits w/ guttrons papules
    Anti-Jo1 autoantibody - violet flat top lesion
  280. Dermatitis Herpetiformis
    IgA antibody
  281. Erythema multiforme
    Viral hepatitis associated with target lesions
  282. Imptigo - staph aruea (cat / coagulase pos)
    Honey crusted pyogenic infx
  283. Lichen Planus - assoc w/ chronic hep c virus
    Pruritic planar purple papules
  284. Necrotizing Fascitits
    Group A strep 2nd to Varicella infx
  285. Stevens johnson (>10% of body)
    Bullous erthyema multiforme
  286. Toxic epidermal necolysis
    Severe SJS (slough + bullus) w/ >30% of body
  287. Superfial spreading melanoma
    Melanoma: plaques w/ blue-black spots
  288. Nodular melanoma
    Melanoma: rapid growing dark papule
  289. Lentigo meligna melanoma
    Melanoma: Brown macule on sen exposed face
  290. Acral lentiginous melanomas
    Melanoma: AA on palms feet toe
  291. Basal cell CA (may effect eye)
    Shiny pearly nodule or ulcerated nodule on eyelid
  292. Squamous cell CA
    Red papule or crusted on lower lip
  293. Gouty arthtis
    Swelling
  294. Reumatoid arthtis
    small joints
  295. Degenerative osteoarthritis
    erosion and loss of articular cartilage osteophytes
  296. Osteomyelitis
    infection that produces marked bone deformity
  297. Pseudogout
    Rhoboid cyrstals
  298. Osteomalacia
    lacking in vitamin D
  299. Osteogenesis imperfecta
    inherited disorder of type 1 collagen synthesis
  300. chondrosarcoma
    Hip pain w/ blue white cut surface
  301. Osteosarcoma
    most frequent primary malignancy of bone
  302. osteosarcomas
    associated with Paget disease of bone
  303. Ewing sarcoma t(11:22)
    'small round blue cell' tumor of bone in kids
  304. Salmonella
    African w/ sickle cell and back pain (osteomyelitis)
  305. Pagets dz of the bone (risk for cardiac failure)
    Sclerosis
  306. occur in the metaphyseal region
    Osteosarcomas.
  307. diaphysis
    Ewing sarcoma
  308. Prostate Ca
    Mets cuase Osteoblastic lesions in spine
  309. Mult Myoloma (monoclonal IG w/ plasma cells)
    Mets cuase osteolytic lesions (+bence jones)
  310. Osteosarcoma
    Atypical long cell w hyperchromatic nuclei n osteoid
  311. Osteosarcoma (codmans)
    metaphysis mass eroding cortex
  312. Osteoporosis
    Complication of long-term corticosteroids use
  313. Rickets/Osteomalacia
    Def of vitamin D in kids/adults with growing bones.
  314. Osteochondroma
    Lateral projection
  315. Giant cell tumor
    Reactive multinculeated giants
  316. Osteoid osteoma
    small nidus is surrounded by sclerotic bone
  317. Endochondroma -Ollier dz (many of them)
    Benign cartilage tumor of hands and feet
  318. Paget dz of bone (complication = heart failure)
    mosaic ostiod w both increased Blast/Clast activity
  319. Osteitis fibrosa cystica
    'brown tumor'hyperparathyroidism
  320. Neisseria gonorrheae infection
    20 male acute artiths
  321. Osteogensis imperfecta (def in type1 collagen)
    Blue sclerae
  322. Osteopetrosis (dt carbonic anhydrase def) (AD)
    Defect in osteoclasts w thickened
  323. Achondroplasia (bad endochondrial bone form)
    Dwarfism dt mutated EGFR3
  324. Autosomal dominant
    OI type II
  325. Inc risk for osteosarcoma
    Retinoblastoma mutation
  326. achondroplasia
    Fibroblast growth factor receptor 3
  327. ankylosing spondylitis
    HLA-B27 ipositive in which spine lesions
  328. Osteoid osteoma (pain releived by asprin)
    Nidus covered by sclerosis
  329. Hyperparathryoidism = osteitis fibrosa cystica
    Patient in Renal Failure (BUN/Creatine)
  330. Giant cell tumor of bone
    epiphyseal of femur with a "soap bubble"
  331. Osteosarcoma
    Metaphyseal
  332. Chondrosarcomas
    chondrocytes with cartilagenous matrix
  333. Ewing Sarcoma (Onion skin) t11:22
    Small round blue cells of primitive neuroectoderm
  334. osteosarcoma
    Osteoid production by a malignant bone neoplasm
  335. RA complication - rheumatoid nodule
    granulomatous inflammation seen in soft tissues
  336. Osteoarthritis
    Cartilage erosion
  337. Osteosarcomas
    malignant spindle cells within an osteoid matrix.
  338. Duchenne muscular dystrophy (xlink recssive)
    fibrosis w atrophy of fibers pseudohypertrophy
  339. Myotonic dystrophy is an (AD) disease
    cataracts
  340. Polymyositis-dermatomyositis
    Jo-1 antibody mediated by cytotoxic CD8 Tcells
  341. Duchenne muscular dystrophy
    lack of dystrophin staining
  342. Becker muscular dystrophy.
    Reduced Dystrophin staining
  343. Myotonic dystrophy (AD) w/ ring fibers
    CTG repeats in a gene for myotonin protein kinase
  344. Lambert-Eaton syndrome
    Auto antibodies to presynaptic Ca++ channels
  345. Dermatomyositis
    HLA-DR3 phenotype
  346. Urticaria Pigmentosa
    Mastocytosis in children
  347. Type 1 Hypersensitivity (urticaria
    angioedema)
  348. Type 2/3 HST (pemphigus vulgaris
    bullous pemphigoid)
  349. Type 4 HST (Poison Ivy reaction
    Contact Dermatitis)
  350. Spongiosis (Edema)
    Eczematous lesions all maintain the following
  351. Mastocytosis
    Darier's Sign
  352. Mastocytosis
    Dermatographism
  353. Erythema Multiforme
    Target Like Lesions
  354. Stevens-Johnson Syndrome
    EM with Fever and Oral/Mucosal Lesions
  355. Darier's Sign
    Wheal that forms after rubbing
  356. Dermatographism
    dermal edema after stroking skin
  357. Erythema Multiforme
    Type IV reaction
  358. Psoriasis
    Silver plaques
  359. Parakeratosis
    Nuclei present in Stratum Corneum Cells
  360. Koebner's Phenomenon
    Psoriatic lesions appearing after Trauma
  361. Psoriasis
    HLA-C association
  362. Psoriatic Arthritis
    HLA-B27 association
  363. Munro Microabscesses(Psoriasis)
    Neutrophils in the parakeratotic stratum corneum
  364. Auspitz Phenomenon
    Removing Scale on Psoriatic Lesion causes bleeding
  365. Lichen Planus
    Purple lesions with White Wickham Striae
  366. Psoriasis
    Lichen Planus
  367. Lichen Planus
    Saw-toothing
  368. Civatte body (colloid body)
    Necrosing basal cells within papillary dermis
  369. Dermatitis Herpetiformis
    Celiac Sprue
  370. Dermatitis Herpetiformis
    Pruritic papulovesicles of extensor surfaces and butt
  371. Dermatitis Herpetiformis
    Granular deposition of IgA to transglutaminase 2
  372. Nikolsky's Sign
    Upon Pressure able to enlarge flaccid blister
  373. Pemphigus Vulgaris
    Nikolsky's sign
  374. Pemphigus Vulgaris
    Intraepidermal IgG deposition to Desmoglein 3
  375. Bullous Pemphigoid
    Linear deposition of complement on dermo-epi jxn
  376. Bullous Pemphigoid
    Subepidermal
  377. Keratoacanthoma
    Crateriform tumor with central keratin plug
  378. Keratoacanthoma
    Sun exposed skin or de novo
  379. Squamous Cell Carcinoma
    Actinic Keratosis is a precursor lesion to
  380. Squamous Cell Carcinoma
    Epithelial cells with keratin pearls
  381. Pyrimidine Dimers
    Where p53 mutations in Actinic Keratosis happen
  382. p53
    DNA damage by UV radiation
  383. Xeroderma Pigmentosum
    Inherited mutation in nucleotide excision repair pathway
  384. Malignant Melanoma
    ABCDEs (Asymmetry
  385. Trunk
    Location where Malignant Melanoma is worst
  386. Breslow levels of vertical growth AKA depth
    Most important prognostic factor for Malignant Melanoma
  387. superficial spreading (radial phase)
    Most common type of malignant melanoma presentation
  388. Nodular (goes straight to vertical phase)
    Poorest prognostic presenation of malignant melanoma
  389. Acral Lentiginous Melanoma
    Palms
  390. 0.75 mm
    1.7 mm
  391. Lentigo Maligna
    Huntington's Freckle
  392. Dermatofibroma (histiocytoma)
    Scar like tissue in deep dermis maybe after trauma
  393. Junctional Nevus
    Nevus with melanocytes in the epidermis at the dermal border
  394. Compound Nevus
    Nevus with melanocytes in both the epidermis and dermis
  395. Intradermal Nevus
    Nevus with melanocytes leaving the epidermis
  396. Basal Cell Carcinoma
    Sites of chronic sun exposure
  397. Basal cell carcinoma
    Palisading nuclei
  398. Actinic Keratosis
    Pearly gray-white scaly flat lesions in older patients
  399. Vitiligo
    Idiopathic/autoimmune loss of melanocytes
  400. Albinism
    Autosomal recessive disease with melanocytes present but lack of tyrosinase
  401. Lentigo
    Benign proliferation/hyperlasia of melanocytes
  402. Acanthosis Nigricans
    Diffuse dark brown velvety plaques in flexor regions of skin
  403. Acanthosis Nigricans
    Lesion associated with gastric adenocarcinoma and lung cancer
  404. Diabetes or other endocrine abnormality
    Common cause of acanthosis nigricans in younger patients (benign)
  405. Acanthosis Nigricans
    Dermal papillae form peaks and valleys
  406. Seborrheic Keratosis
    "stuck on" lesions
  407. Leser-Trelat sign
    Paraneoplastic syndrome of seborrheic keratosis from GI cancers
  408. Mycosis Fungoides
    CD4 T cell lymphoma in the skin
  409. Mycosis Fungoides
    Sezary Lutner cells
  410. Tinea Versicolor
    Malessezia furfur
  411. Verruca vulgaris (HPV)
    Dorsal surface of hands
  412. Malignant Melanoma
    CDKN2A (chromosome 9)
  413. Rosacea
    Late stage hyperplasia of nose sebaceous glands
  414. Rhinopyma
    Permanent thickening of nasal skiin
  415. Nevoid BCC Syndrome (Gorlin Syndrome)
    Autosomal Dominant PTCH mutation on Chromosome 9
  416. Xanthoma
    Yellow lesions
  417. Acne Vulgaris
    Comedones with keratin blockage
  418. Pemphigus vulgaris
    Acantholysis (separation of desmosomes
  419. Melasma/Chloasma
    Pregnancy mask
  420. Lupus
    Butterfly Rash
  421. Molluscum Contagiosum (Poxvirus)
    Bowl shaped lesions with ulceration

What would you like to do?

Home > Flashcards > Print Preview