What are 3 important causes of endothelial dysfunction?
1. hemodynamic disturbance: plaques have a tendency to form at ostia (opening) of exiting vessels, branch points, & along the posterior wall of the abdominal aorta where they disturbed flow patterns
2. lipoprotein abnormalities: can result from gene mutations, dyslipoproteinemia, ↑ LDL, ↓ HDL
3. inflammation: inflam. cells & mediators are directly responsible for the initiation, progression, & complications of ATH lesions (eg. foam cells, + T-cells in the intima generate a chronic immune inflammatory state)