thera 4 test 1 RA other stuff

Card Set Information

Author:
coal
ID:
262245
Filename:
thera 4 test 1 RA other stuff
Updated:
2014-02-16 15:01:36
Tags:
thera test RA other stuff
Folders:
thera 4 test 1 RA other stuff
Description:
thera 4 test 1 RA other stuff
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user coal on FreezingBlue Flashcards. What would you like to do?


  1. definition of hyperuricemia
    uric acid level > 6.5 mg/dL
  2. colchicine - colysry (4)
    • inhibits neutrophils
    • best to use within the first 24 hours of attack
    • avoid in renal impairment
    • metabolized by CYP3A4
  3. 2 indications for pharmacologic treatment of chronic gout
    • pt with > 2 acute attack/year
    • pt w tophi or nephrolithiasis
  4. allopurinol - aloprim (2)
    • XOI
    • renal adjustment
  5. februxostat - uloric (2)
    • XOI
    • not studied in CrCl < 30 mL/min
  6. probenecid (4)
    • inhibits reabsorption of uric acid
    • avoid in CKD
    • ineffective if CrCl < 50 ml/min
    • can increase concentration of penicillins, cephalosporins, sulfonamides & indomethacin
  7. pegloticase (krystexxa) (3)
    • converts uric acid to allantoin
    • pre-medicate with antihistamine & corticosteroids
    • CI - G6PD deficiency
  8. gout Tx algorithms
    1st line XOI, 2nd line probenecid

    Add probenecid

    Then go to pegloticase - krystexxa
  9. 5 risk factors for osteoporosis
    • age
    • hormone deficiency
    • body habitus
    • social history
    • medical history
  10. medication risk factors for osteoporosis
    • VA PALATE CLAIMS
    • Vitamin A excess
    • Aromatase inhibitors
    • PPI's
    • AIDS/HIV
    • Loop diuretics
    • Antiepileptic
    • TZD's
    • Excessive thyroid hormone (levothyroxine)
    • Corticosteroids
    • Lithium
    • Anticoagulants
    • Immunosuppressants
    • Medroxyprogesterone
    • SSRIs/TCAs
  11. WHO diagnostic criteria T-score
    • > -1.0 = normal
    • -1.0 & -2.5 = osteopenia
    • < -2.5 oseoporosis
  12. RDA calcium
    • adult males and females = 800-1300mg
    • pregnant females = 1300 mg
    • postmenopausal women & men >50 = 1200mg
  13. calcium misc. facts
    • DI: phenytoin, tetracyclines, fluoroquinolones
    • fraction absorbed decrease with dose, so divided doses are recommended (500-600 mg or less)
    • calcium carbonate - should be taken w/meals to enhance absorption
    • calcium citrate is acid independent
  14. efficacy of bisphoshonates
    for preventing vertebral fractures
  15. counseling points for raloxifene for evista
    • D/C at least 72 hours prior to and during prolonged immobilization
    • increase risk of VTE
  16. safety concerns for denosumab - prolia
    • atypical femur fractures
    • increase risk of infections
    • osteonecrosis of the jaw

What would you like to do?

Home > Flashcards > Print Preview