Health science 2211- Module 2 lecture 1

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CanuckGirl
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Health science 2211- Module 2 lecture 1
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2014-03-15 16:00:16
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The wild cells
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  1. Cancer is the leading cause of death worldwide affecting 1 in _ persons in the world
    4
  2. what are some major types of cancer? (5)
    lung, stomach, colorectal, prostate and breast cancers
  3. Define cancer.
    is a disorder of cellular growth and differentiation characterized by uncontrolled and rapid growth
  4. Define a cell.
    basic unit of life, made of molecules in the form of carbohydrates, lipids, nucleic acids and proteins
  5. what are the 4 main functions of cells through which multicellular organism functions properly?
    • cell proliferation
    • cell specialization
    • cell interaction
    • cell movement
  6. cell division is the basis for what 3 things?
    • growth
    • regeneration
    • repair
  7. cells divide through the sequence of events called __________.
    cell cycle
  8. what happens during the cell cycle?
    cell duplicates its genetic material (DNA/chromosome) and each daughter cell receives a copy
  9. cells are stimulated to do what 3 things? what do these outcomes depend on?
    • to divide, not to divide, and die
    • stimulatory or inhibitory interactions
  10. The transformations of a normal cell into a cancerous cell is the result of?
    changes to its DNA (mutations) that accumulate over time
  11. Cancer cell growth results in? (6)
    • loss of functionality of the cell
    • rapid cell division
    • tumor =accumulation of abnormal cells
    • possible growth of cells beyond the tissue border
    • invasion into other tissues
    • metastasis= spread to the rest of the body
  12. what is metastasis?
    spreading of cancerous cells to the rest of the body
  13. Cancer can arise from one of two processes, what are they?
    • cells have escaped the usual growth regulators. with no controls reproduction goes non-stop. (most cases)
    • cells that would normally undergo apoptosis, don't
  14. what is apoptosis?
    death of a cell
  15. what are the 3 germ layers and name 2 types of cells/tissue for each germ laye.
    • endoderm: lung cell, thyroid cell
    • mesoderm: cardiac muscle, skeletal muscle cells
    • ectoderm: skin cells of epidermis, neuron of brain
  16. what is mesenchyme? where are they originated from?
    • supportive/connective tissues in organs and the cells that produce them
    • cells are of mesodermal origin
  17. what is parenchyma? where is it originated from?
    • cells in an organ
    • typically of endodermal origin in viscera
    • parenchyma cells are surrounded and supported by connective tissue
  18. which tissues do most tumors arose from?
    epithelial tissues
  19. what are the 4 principle types of tissues?
    • epithelial tissue
    • connective tissue
    • muscle tissue
    • nervous tissue
  20. what is the function of epithelial tissue? (3)
    covers body surfaces, line hollow organs, body cavities and ducts; and forms glands
  21. what is the function of connective tissue? (4)
    protects and supports the body and its organs, binds organs together, stores energy reserves as fat, and provides immunity
  22. what is the function of muscle tissue?
    is responsible for movement and generation of force
  23. what is the function of nervous tissue?
    initiates and transmits action potentials (nerve impulses) that help coordinate body activities
  24. what is epithelium?
    cells lining internal surfaces and external surfaces of the body, including the outer layer of the skin, surface of most tubules, body cavities and lumen of organs (lungs, gut, kidney)
  25. what are the 2 main types if epithelium, briefly describe both.
    • simple: only one layer of cell
    • stratified: many layer of cells
  26. describe the basement membrane.
    2 layers of dense acellular matrix: a basal lamina (secreted by epithelial cells) and a reticular lamina (secreted by underlying reticular cells)
  27. what are the 3 jobs of stem cells?
    • divide
    • keep one daughter as a stem cell
    • tell other daughter to differentiate
  28. What is the first stage of tumor growth/cancer? briefly describe it.
    hyperplasia: refers to tissue growth based on an excessive rate of cell division, leading to a larger than usual number of cells
  29. what is the second stage of tumor growth/cancer? briefly describe it.
    Dysplasia: an abnormal type of excessive cell proliferation characterized by loss of normal tissue arrangement and cell structure
  30. what is the third stage of tumor growth/cancer? Briefly describe it.
    carcinoma in situ: uncontrolled growth of cells that remains in the original location. Severe dysplasia
  31. what is the fourth stage of cancer/tumor growth?
    Cancer (invasive)
  32. Define neoplasm/neoplasia. what's an example?
    • means "new growth"
    • abnormal tissue growth because of abnormal cellular-reproduction
    • ex. warts
  33. define aberrant cellular growth. (2)
    • alteration in normal cell growth
    • typically the growth is clonal, uncorrdinated and autonomous, which arises due to genetic changes
  34. Define carcinogenesis.
    production or origination of cancer cells
  35. Define tumor. Name the 2 types of tumors.
    • growth of neoplastic cells clustered together to form a mass (solid mass of clonal cells)
    • 2 types: benign or malignant
  36. Define a benign tumor.
    characterized by abnormal cell division but no metastasis or invasion of the surrounding tissues
  37. Define a malignant tumor.
    abnormal cell division characterized by ability to invade locally, metastasize and reoccur.
  38. Define metastasis.
    ability to establish secondary tumor growth at a new location away from the primary tumor.
  39. Cancer is clonal. what is the meaning of this?
    all cancerous cells in a tumor are derived from a single cell
  40. The conversion of a single cell to a cancerous cell occurs in steps, with each step governed by a __________.
    mutation
  41. Mostly tumors are monoclonal, what does this mean? how is the mutation spread?
    • meaning one cell origin
    • mutation in a single cell can be spread via its offspring
  42. Cancer cells become ____________ as they become malignant. How do they become this?
    • heterogeneous
    • different cells gain different mutations , while all cells keep their initial mutations
  43. List 7 characteristics of benign tumors.
    • similar to cell of origin
    • edges move out word smoothly
    • compress locally
    • slow growth rate
    • seldom recur after removal by surgery
    • necrosis and ulceration is uncommon
    • systematic effect is uncommon
  44. List 7 characteristics of malignant tumors.
    • dissimilar from cell of origin
    • edges move out ward irregularly
    • invade locally
    • rapid to very rapid growth rate
    • frequently recur after removal by surgery
    • necrosis and ulceration common
    • systematic effect common
  45. what are the 2 pieces of information used to name tumors?
    • based on behaviour of growth (benign or malignant)
    • based on cells of origin
  46. where is the origin of this suffix?  "oma"
    benign= "oma" at the end of connective tissue origin tumors
  47. Where are the origins of these malignant suffixes? "sarcoma", "carcinoma", adenocarcinoma" "-emia"
    • "sarcoma": connective or muscle tissue origin
    • "carcinoma": epithelial origin
    • "adenocarcinoma": glandular origin
    • "-emia": blood cancers
  48. what are some common carcinomas? (epithelial origin) (5)
    • lung
    • breast (women)
    • colon
    • bladder
    • prostate (men)
  49. where can leukemia and lymphomas be found?
    • bloodstream
    • lymph nodes
  50. what are some common sarcomas? (3)
    • bone
    • fat
    • muscle
  51. Name the origins of these benign tumors: lipoma, osteoma, hemangioma, and fibroma.
    • lipoma: fatty cells
    • osteoma: bone cells
    • hemangioma: blood vessels
    • fibroma: fibrous tissue
  52. Describe how these descriptive terms classify tumors: papillary, medullary, scirrhous
    • papillary: tumors have "frond-like" shape
    • medullary: tumors don't have much connective tissue so they tend to be soft
    • scirrhous: tumors have lots of connective tissue so they tend to be firm
  53. what is the stroma? what is it also known as?
    • stroma: ECM, connective tissue, blood vessels, immune cells and other cells
    • also known as microenvironment
  54. why is tumor growth dependent on the stroma? what does an increase and decrease in stroma result in?
    • stroma provides nutrients and growth signals among other factors
    • decrease in stroma= soft tumor
    • increase in stroma=desmoplasia
  55. what are the 4 detectable changes in the physical properties of the cancer cells? briefly describe each.
    • cytoskeletal changes: changes in cytoskeleton affects cell adhesion and motility
    • cell adhesion/motility: reduction of cell to cell ratio allows large masses of cells to form and limits motility
    • nuclear changes: shape and organization of nuclei diff from normal cell
    • Enzyme production: digest away barriers to migration and spread of tumors
  56. Compare microscopic appearance of cancer cells and normal cells.
    • normal:
    • large cytoplasm
    • single nucleus
    • single nucleolus
    • fine chromatin

    • Cancer:
    • small cytoplasm
    • multiple nuclei
    • multiple and large nucleoli
    • coarse chromatin

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