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  1. Which antiepileptics target Na channels?
    Phenytoin, Carbamazepine, Oxcarbazepine, Primidone, Valproate , Lamotrigine, Felbamate(partially), Topirimate (Maybe), Zonisamide (maybe), Rufinamide, Lacosamide
  2. Which Antiepileptics increase GABA at GABAnergic terminals?
    Phenobarbitol, Valproate, Clonazepam, Ezotigabine, Benzodiazapines, Felbamate, Tigabine, Topiramate, Vigabatrin, Zonisimide
  3. Which antiepileptics interact with Ca channels?
    Ethosuximide, Gabapentin, Phenobarbitol, Pregambin, Zonisimide
  4. Which antiepileptics involve T-type Ca Channels?
    Ethosuximide and Zonisamide
  5. Which Anti-epileptic drug has less sedation that phenobarbital, high efficacy, acts similarly to Carbamazepime, targets Na channels, has low selectivity (interacts with K and Ca channels), is contraindicated in Pregnant women, has zero order kinetics and a variety of adverse effects including: Fetal hydantoin, exacerbates absence seizures, ataxia, coarsening of facial features and Hirsuitism?
  6. Which antiepileptics can exacerbate absence seizures?
    Phenytoin, Carbamazepine, Primidone, Lamotrigine, Phenobarbitol
  7. Which antiepileptics can exacerbate atonic seizures?
    Primidone, Phenobarbitol
  8. Which antiepileptics are teratogenic or CI in pregnancy?
    Valproate, Phenytoin, Topirimate (in animal models)
  9. Which antiepileptic has interactions with other antiepileptics?
    Valproate, Carbemazepine, Phenytoin, Primidone
  10. Which Antiepileptics target T type Ca channels?
  11. Which Antiepileptics interact with Ca channels?
    Ethosuximide, Gabapentin, Penobarbitol, Pregamblin and Zonisamide
  12. Which antiepileptics are broad Spectrum, making them good initial choices in most adult patients regardless of type of seizure or syndrome?
    Valproate, lamotrigine, topiramate, levetiracetam and zonisamide
  13. Which antiepileptics are Narrow Spectrum, which restricts them to patients who have focal epilepsy with partial and secondarily generalized seizures?
    Carbamazepine, phenytoin, gabapentin, tiagabine, oxcarbazepine and pregabalin
  14. Which antiepileptics have a very narrow therapeutic window?
    Phenytoin, Carbemazepine, Primidone, Phenobarbitol, Valproate, Ethosuximide
  15. Which drugs are used for absence seizures?
    Ethosuximide, Clonazepam and Lamotrigine
  16. Which drugs can be used for status epilepticus?
    Clonazepam, Diazepam, Lorazepam
  17. Which antiepileptics can be used for partial seizures?
    Carbemazepine (most effective), Phenobarbitol, Primidone, Vigabatrin, Felbamate, Topirimate, Tiagabine, Zonisamide, Gabapentin, Levatiracetam
  18. Which antiepileptics can be used for generalized tonic clonic seizures?
    Topirimate, Valproate, Tiagabine, Phenobarbitol and Primidone
  19. Which antiepileptics are promote GABA inhibition?
    Tiagabine, Barbituates (Phenobarbitol), Benzodiazapines, Valproate and Viagabatrin
  20. Which antiepileptics can cause aplastic anemia?
    Felbamate and Carbemazapine
  21. Which antiepileptics have minimal interactions with other antiepileptics?
    Zonisamide, Tiagabine, Topirimate, Gabapentin, Levatiracetem
  22. Which antiepileptics synaptic vesicle protein 2A?
  23. Which antiepileptics target α2δ type 1 and 2 subunits of voltage-gated calcium ion channel?
    Gabapentin and Pregamblin (Lyrica)
  24. Which antiepileptics are Allosteric modulators of KCNQ2-5 K+ channels, shifting the cell toward a hyperpolarized state?
  25. Carbamazepine interacts with what other antiepileptics? Describe the reactions.
    Phenytoin = Increased metabolism of carbamazepine; phenobarbital = Increased production of epoxide.
  26. Phenytoin interacts with what other antiepileptics? Describe the reactions.
    Primidone = Increased conversion to phenobarbital
  27. Valproic acid interacts with what other antiepileptics? Describe the reactions.
    Phenobarbital = Decreased metabolism, increase toxicity; Phenytoin = Displacement from binding, increased toxicity.
  28. Ezogabine
  29. Pregamblin
  30. Levetiracetem
  31. Phenytoin
  32. Carbamazepine
  33. Phenobarbitol
  34. Oxcarbazepine
  35. Primidone
  36. Ethosuximide
  37. Clonazepam
  38. Lorazepam
  39. Diazepam
  40. Which Antiepileptic binds to α2δ subunits of calcium channel?
    Gabapentin and Pregamblin
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