Therapeutics - HTN

Card Set Information

Author:
kyleannkelsey
ID:
263332
Filename:
Therapeutics - HTN
Updated:
2014-02-24 00:58:47
Tags:
Therapeutics HTN
Folders:
Therapeutics - HTN
Description:
Therapeutics - HTN
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user kyleannkelsey on FreezingBlue Flashcards. What would you like to do?


  1. Drugs that can cause HTN:
    • NSAIDs/COX-2 inhibitors
    • Corticosteroids
    • Estrogens/oral contraceptives
    • Triptans
    • Cyclosporine and tacrolimus
    • Decongestants
    • Erythropoietin
    • Nicotine
    • Anabolic Steroids
    • Cocaine, amphetamines, other illicit drugs
    • Some OTC dietary supplements
    • Ma huang, bitter orange
    • (None could estimate the careful decisions every Native American could someday make)
  2. “Preferred” antihypertensive combinations for uncomplicated hypertension:
    • ACEI or ARB + Diuretic
    • ACEI or ARB + CCB
  3. “Acceptable” combinations of antihypertensive combinations for uncomplicated hypertension:
    • Thiazide + BB
    • Thiazide + CCB
    • Thiazide + aliskiren
    • Thiazide + K+-sparing diuretic
    • BB + dihydropyridine CCB
    • Aliskiren + CCB
  4. “Not preferred combinations” of antihypertensives for uncomplicated hypertension:
    • ACEI + ARB
    • ACEI or ARB + BB
    • Nondihydropyridine CCB + BB
    • Methyldopa + BB
    • Clonidine + BB
  5. Initial antihypertensive choice for Non-black patients according to JNC8 for uncomplicated hypertension:
    • Thiazide diuretic
    • CCB
    • ACEI
    • ARB
  6. Initial antihypertensive choice for Non-black patients (general with stage 1 or lower BP) according to ASH/ISH for uncomplicated hypertension:
    • Age <60: ACEI or ARB
    • Age ≥60: CCB or Thiazide diuretic
  7. Initial antihypertensive choice for Black patients according to JNC8 for uncomplicated hypertension:
    • Thiazide diuretic
    • CCB
  8. Initial antihypertensive choice for Black patients (stage 1 or lower BP) according to ASH/ISH for uncomplicated hypertension:
    • CCB
    • Thiazide diuretic
  9. Initial antihypertensive choice for patient with a BP >160/100 according to JNC8 for uncomplicated hypertension:
    No special recommendation, just give according to whether they are Black or of another race’
  10. Initial antihypertensive choice for patient with a BP >160/100 according to ASH/ISH for uncomplicated hypertension:
    Thiazide diuretic or CCB + ACEI or ARB
  11. First line agent for HTN with Left ventricular function:
    Diuretic + ACEI or ARB + BB
  12. Second line agent for HTN with Left ventricular function:
    Aldosterone antagonist
  13. First line agent for HTN Post-MI:
    BB + ACEI or ARB
  14. First line agent for HTN with Stable Angina:
    BB + ACEI or ARB
  15. First line agent for HTN with Chronic Kidney Disease:
    ACEI or ARB
  16. First line agent for HTN with Diabetes:
    ACEI or ARB
  17. First line agent for HTN undergoing recurrent stroke prevention:
    Thiazide diuretic + ACEI
  18. Most potent/efficacious thiazide diuretic:
    Chlorthalidone
  19. Thiazide diuretics:
    • Hydrochlorothiazide (HCTZ)
    • Chlorthalidone
    • Metolazone
    • Indapamide
  20. Thiazide diuretic that does not need dose adjustment and can be used when CrCl <30:
    Metolazone
  21. Loop diuretics:
    • Furosemide
    • Bumetanide
    • Torsemide
    • Ethacrynic acid
  22. Which loop diuretic can be given if a patient has a Sulfa allergy?
    Ethacrynic acid
  23. Are Loop, K-sparing diuretics or Thiazide diuretics better for HTN?
    Thiazides
  24. # of times a day need to give Loop diuretics for HTN:
    2-3 (exception, Torsemide: once daily)
  25. What are the K-sparing (not aldosterone antagonists) diuretics?
    • Triamterene
    • Amiloride
  26. What is the MOA of K-sparing (not aldosterone antagonists) diuretics?
    Blocks Na reabsorption in the late distal tubule
  27. Which is the least effective for HTN: Loop, K-sparing or Thiazide diuretics?
    K-sparing, ineffective for HTN: only used as an adjunct to counteract K loss
  28. What are the Aldosterone antagonsists?
    • Eplerenone
    • Spirolactone
  29. What is the MOA of aldosterine antagonists?
    Blocks aldosterone receptor → modulates vascular tone
  30. When would you use an Aldosterone antagonist for HTN?
    • Resistant HTN
    • HF patient (LV dysfunction)
    • Hypokalemia from other diuretic therapy
  31. What drug has been well studied and is found to be useful in many resistant cases of HTN?
    Aldosterone antagonists
  32. Which Aldosterone antagonist has fewer allergies due to selectivity?
    Eplerenone
  33. Hyperuricemia is most common with what type of diuretic?
    Thiazide diuretics

What would you like to do?

Home > Flashcards > Print Preview