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- Decreases acid concentration in GI tract and elevate stomach pH>5
- Take on empty stomach, 1-3 hrs after meals and at bedtime.
- Magnesium causes diarrhea
- Aluminum causes constipation and hypophosphatemia.
- Calcium causes constipation
- Sodium bicarbonate causes alkalosis.
H2 Receptor Antagonists (ine)
Cimetidine, Ranitidine, Famotidine, Ranitidine
- Avoid taking an antacid 1 hour before and 1 hour after H2 blocker
- Reduces hydrochloric acid in stomach. Used for GERD, heartburn, erosive esophagitis.
- Do not stop arubtly
- Drug of choice for PUD - gastric and duodenal ulcers
- Decreased platelets
- Carafate - promotes ulcer healing by adhering to ulcer surface and forming a protective barrier against gastric acid and pepsin
- Take on empty stomach 1hr before meal
- Do not crush or chew
- Other meds should be taken 2 hrs before or after this medication.
- Temporary darkening (gray-black) stool
- Contains salicylate - observe for tinnitus, give cautiously to children due to possibility of Reyes syndrome
- Antibacteria action against H. pylori
- Cytotec - suppresses gastric acid and increase the production of protective mucus
- Contraindicated in pregnancy
- Given concurrently with long term NSAIDs to prevent NSAID induced gastric & duodenal ulcers
Proton Pump Inhibitors (PPI) (prazole)
- Used in GERD, duodenal ulcers, esophagitis and H.pylori infections
- Most effective drugs for suppressing secretion of gastric acid
- Can cause irreversible inhibition of gastric acid pump in the stomach
Simethicone (Mylicon, Gas-X)
- Monitor stools for high fat content. Stools will be foul-smelling and frothy if patient does not have enough enzymes
- Administer immediately before or with meals and snacks
- Eat immediately after taking medication. Do not chew tablets, drink with plenty of fluids.
- Abdominal cramping
- F&E imbalance
- Bulk forming laxative must take with fluid. If taken without adequate fluid it may cause it to swell and block the throat or esophagus and may cause choking
- Hyperosmolar acts quickly in 6-12 hours or as rapidly as 2-4 hours.
- Used for diagnostic tests; colonoscopy
- can cause substantial water loss
- Management of GERD, decrease symptoms of gastric stasis
- Drowsiness, difficulty speaking or swallowing, loss of balance control
- Anticholinergic for mild or modere N/V
- Reglan for mild or moderate N/V
- Uncontrolled rhythmic movement of mouth, face and extremities, lip smacking or puckering
- Zofran for high or moderate N/V
- Used in ulcerative colitis and Crohn's disease
- Suppresses the immune system
- Infection due to long term use
- Na and water retention, K loss
- Puffy face
- Growth retardation
- Used to treat mild or moderate ulcerative colitis or Crohn's disease
- Belongs to sulfonamides antibiotics
- Reduces inflammation
- Take 1 to 2 hrs before meals, full glass of water
- Blood disorders, Nausea, fever, rash
- For long term treatment of ulcerative colitis and Crohn's disease
- To induce and maintain remission
- Acts as immunosuppressant