Therapeutics IHD

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Author:
kyleannkelsey
ID:
263610
Filename:
Therapeutics IHD
Updated:
2014-02-23 23:24:05
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Therapeutics IHD
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Therapeutics IHD
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  1. What drugs should all IHD patients be on?
    Aspirin, Statin, BB and ACEI
  2. When could CCBs be used for IHD?
    If BBs are not tolerated
  3. Do Nitrates have a mortality benefit for IHD?
    No, symptomatic relief only
  4. Some patients are not on all four IHD drugs, which one is often not tolerated or CI and has to be eliminated?
    ACEI
  5. What benefit do CCBs have for IHD?
    Angina pain relief
  6. Aspirin dose for IHD:
    81-325 mg/day
  7. MOA of aspirin:
    Antiplatelet drug - Inhibits formation of thromboxane A2 by irreversible inhibition of COX1
  8. BBs reduce mortality by what amount?
    23%
  9. How long should patients remain on BBs?
    3 years minimum
  10. BBs are proven to have what benefits?
    • Reduced mortality
    • Reduced frequency of symptoms
    • Improved exercise tolerance
    • Reduce chest pain
  11. What is the MOA for BBs in the treatment of IHD?
    Decrease O2 demand, Contractility, HR, Wall tension and Renin
  12. B1 selective BBs:
    • Atenolol (Tenormin)
    • Bisoprolol (Zebeta)
    • Metoprolol tartrate (Lopressor)
    • Metoprolol succinate (Toprol XL)
    • Nebivolol (Bystolic)
  13. Atenolol 
    Tenormin
  14. Bisoprolol 
    Zebeta
  15. Metoprolol tartrate 
    Lopressor
  16. Metoprolol succinate 
    Toprol XL
  17. Nebivolol 
    Bystolic
  18. Should you start low and titrate up or start at a target dose with BBs?
    Start low and titrate up
  19. ACEIs should be used in all patients with IHD who also have what conditions?
    • Diabetes
    • CKD
    • HTN
    • LV systolic dysfunction (EF < 40%)
  20. ACEIs for IHD:
    • Captopril (Capoten)
    • Enalapril (Vasotec)
    • Lisinopril (Prinivil)
    • Ramipril (Altace)
  21. Captopril 
    Capoten
  22. Enalapril 
    Vasotec
  23. Lisinopril 
    Prinivil
  24. Ramipril 
    Altace
  25. ARBs for IHD:
    • Trandolapril (Mavik)
    • Candesartan (Atacand)
    • Valsartan (Diovan)
    • Losartan (Cozaar)
    • Irbesartan (Avapro)
  26. Trandolapril Mavik
  27. Candesartan 
    Atacand
  28. Valsartan 
    Diovan
  29. Losartan
    Cozaar
  30. Irbesartan
     Avapro
  31. What should you monitor ACEI and ARB use with?
    Electrolytes, Scr, BUN, ↑K+
  32. Captopril is dosed how often?
    2x day
  33. What are the pleiotropic effects of Statins:
    • Anti-inflammatory
    • Antiplatelet
    • Antioxidant
    • ↑ NO
    • Plaque stabilizing

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