Card Set Information
What drugs should all IHD patients be on?
Aspirin, Statin, BB and ACEI
When could CCBs be used for IHD?
If BBs are not tolerated
Do Nitrates have a mortality benefit for IHD?
No, symptomatic relief only
Some patients are not on all four IHD drugs, which one is often not tolerated or CI and has to be eliminated?
What benefit do CCBs have for IHD?
Angina pain relief
Aspirin dose for IHD:
MOA of aspirin:
Antiplatelet drug - Inhibits formation of thromboxane A2 by irreversible inhibition of COX1
BBs reduce mortality by what amount?
How long should patients remain on BBs?
3 years minimum
BBs are proven to have what benefits?
Reduced frequency of symptoms
Improved exercise tolerance
Reduce chest pain
What is the MOA for BBs in the treatment of IHD?
Decrease O2 demand, Contractility, HR, Wall tension and Renin
B1 selective BBs:
Metoprolol tartrate (Lopressor)
Metoprolol succinate (Toprol XL)
Should you start low and titrate up or start at a target dose with BBs?
Start low and titrate up
ACEIs should be used in all patients with IHD who also have what conditions?
LV systolic dysfunction (EF < 40%)
ACEIs for IHD:
ARBs for IHD:
What should you monitor ACEI and ARB use with?
Electrolytes, Scr, BUN, ↑K+
Captopril is dosed how often?
What are the pleiotropic effects of Statins: