neurobio 8 ch 6 of bear's book: neurotransmitter systems part 1 (ACh ligand chatecholaminergic do

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mikepl103
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263703
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neurobio 8 ch 6 of bear's book: neurotransmitter systems part 1 (ACh ligand chatecholaminergic do
Updated:
2014-03-07 10:22:18
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neurobio bear book neurotransmitter systems part ACh ligand chatecholaminergic dopamine norepinephrine epinephrine transmitter gated channels
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2014,biology,neurobiology
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neurobio 8 ch 6 of bear's book: neurotransmitter systems part 1 (ACh, ligand, chatecholaminergic, dopamine, norepinephrine, epinephrine, transmitter-gated channels)
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  1. What i IPSP
    transitter gated ion channels open to conduct Cl. GABA and glycine receptor. Usually causes hyperpolarization.
  2. what are neurons that use ACh called?
    cholinergic
  3. what are the three criteria that a neurotransmitter must have in order to be classified as a neurotransmitter?
    • 1. synthesis and storage in presynaptic neron
    • 2. Relesed by presynaptic axon terminal upon simulation
    • 3. Produces response in postsynaptic cell
  4. what is agonist?
    a chemical that can function as a neurotransmitter itslef
  5. what is antagonist?
    will bind to neurotransmitter receptor and prohibit activity
  6. what is the neurotransmitter of neuromuscular junctions in the body?
    ACh
  7. how can one identify cholinergic neurons in the body?
    by using antibodies that are specific for ChAT enzyme
  8. how is ACh synthesized and destroyed?
    synthesized by ChAT enzyme and destroyed by AChE
  9. what are the three catecholamines?
    dopamine, norepinephrine, and epinephrine
  10. what do dopamine, norephinephrine and epinephrine have in common?
    they all have catechol groups and they are derived from tyrosine
  11. all catecholaminergic neurons contain which enzyme?
    tyrosine hydroxylase (TH)
  12. what major neurotransmitter mediates most of the synaptic inhibition in the CNS?
    GABA mediates most of the inhibition in CNS, while glycine does most of the rest
  13. true or false, nicotinic ACh receptors are only found in skeletal muscle?
    false, they are found in other organs and the CNS as well
  14. what is the basic structure of tansmitter-gated ion channel?
    most are pentameric complexes arranged like the staves of a barrel. each subunit of the complex usually has four transmembrane regions
  15. are nicotinic and muscarinic ACh receptors excitatory or inhibitory?
    excitatory
  16. are ampa gated channels excitatory or inhibitory?
    excitatory
  17. What are AMPA gated channels permeable to?
    sodium and potassium but not calcium
  18. what is the diff between nmda gated and ampa gated channels?
    nmda channels are permable to Ca and the inward ionic current through nmda gated channels is voltage dependent
  19. describe how nmda channels open
    when the nmda gated channel opens, Ca and Na enter the cell but the magnitude of this inward ionic current depends on the postsynaptic membrane potential in an unusual way, for an unusual reason. When glutamate binds the nmda receptor, it becomes opened, but it is clogged by a magnesium ion. Mg pops out of the pore only when the membrane is depolarized, which usually follows the activatio of AMPA channels at the same and neighboring synapses. Thus, inward ionic current through the NMDA channel is voltage dependent.
  20. what receptors does ethanol affect?
    it affects NMDA, glycine, nicotinic ACh, serotonin receptors, and GABAA receptors.
  21. which type of receptor has many binding sites for various drugs?
    GABAA receptor

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