Chapter 11,12,13

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Author:
servinggod247
ID:
263917
Filename:
Chapter 11,12,13
Updated:
2014-02-25 14:23:32
Tags:
pharmacology
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pharmacology
Description:
pharmacology exam 2
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  1. Infection caused by a fungus is called a
    mycosis
  2. Fungus have rigid cell walls made of
    chitin and polysaccharides
  3. Fungus have a cell membrane that contains
    ergosterol
  4. Antifungals work by
    altering cell permeability by affecting ergosterol
  5. Fungal infections are more common in the ____________ and in the _______; infections range from ________ to __________
    • immunocompromised and elderly¬†
    • nuisance to life threatening
  6. What is a prototype antifungal
    fluconazole (Diflucan)
  7. MOA of fluconazole
    affect cell permeability of the fungus resulting in cell death and replication. Affect ergosterol in cell wall through binding and open pores or impair synthesis of ergosterol leading to change in cell permeability
  8. Drug to drug interactions are common with __________. Why?
    antifungals. 

    These drugs inhibit the CYP450 enzyme system needed to metabolize many other medications
  9. Antifungal used to treat skin and mucous membrane infections
    clotrimazole (Lotrimin)
  10. Protozoas are responsible for diseases such as
    • malaria
    • amebiasis (ingestion of contaminated water or food)
    • Leishmaniasis ( transmitted through sand flea bite)
    • trypanosomiasis ( African sleeping sickness with bite of tsetse fly and Chagas disease)
  11. What drug is used to treat trichomoniasis?
    metronidazole
  12. What is Trichomoniasis?
    spread by intercourse from asymptomatic males. Results in vaginal discharge- green, yellow, itching, burning.
  13. What is the most common intestinal parasite in US transmitted through contaminated water or food in form of cysts? Medicine used to treat?
    Giardiasis

    Metronidazole
  14. What is the endemic protozoan that usually does not cause illness in humans but in people with suppressed immune systems may cause a severe pneumonia?
    Pneumocystis carinii
  15. Prototype antimalarial
    chloroquine (Aralen)
  16. Prototype Antiprotozoal agent. Use?
    metronidazole (Flagyl)

    used to reat both giardiasis and trichomoniasis
  17. Anthelmintic Agents deal with
    worms

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