altering cell permeability by affecting ergosterol
Fungal infections are more common in the ____________ and in the _______; infections range from ________ to __________
immunocompromised and elderly
nuisance to life threatening
What is a prototype antifungal
MOA of fluconazole
affect cell permeability of the fungus resulting in cell death and replication. Affect ergosterol in cell wall through binding and open pores or impair synthesis of ergosterol leading to change in cell permeability
Drug to drug interactions are common with __________. Why?
These drugs inhibit the CYP450 enzyme system needed to metabolize many other medications
Antifungal used to treat skin and mucous membrane infections
Protozoas are responsible for diseases such as
amebiasis (ingestion of contaminated water or food)
Leishmaniasis ( transmitted through sand flea bite)
trypanosomiasis ( African sleeping sickness with bite of tsetse fly and Chagas disease)
What drug is used to treat trichomoniasis?
What is Trichomoniasis?
spread by intercourse from asymptomatic males. Results in vaginal discharge- green, yellow, itching, burning.
What is the most common intestinal parasite in US transmitted through contaminated water or food in form of cysts? Medicine used to treat?
What is the endemic protozoan that usually does not cause illness in humans but in people with suppressed immune systems may cause a severe pneumonia?