inhibit synthesis of prostoglandins (mediator of inflammation) Reduces fever (prostoglandins involved in pyrogenic mechanisms). Also inhibits thromboxane A synthesis which affects platelet aggregation and prostocyclin synthesis which impacts and suppresses platelet aggregation
Uses of asprin
blood thinner (prevention of secondary heart attack and stroke), sever arthritis
Aspirin is linked to what syndrome? What is it?
Reyes Syndrome: condition where aspirin and a viral illness combine and it effects ammonia levels in the body causing liver and brain deterioration
Adverse effects of aspirin
upset stomach, nausea
If you are allergic to aspirin, what over the counter pain reliever can you take?
People who are allergic to aspirin cannot take any other non-steroidal anti inflammatory such as
inhiition of prostaglandin synthesis by blocing cyclooxygenase enzymes (COX 1 and COX 2) which are the enzymes that continue progression of inflammation from arachidonionic acid to prostaglandin
COX 1 enzymes
blood vessels, stomach, kidneys
Necessary for normal blood clotting, protecting stomach lining, and proper sodium and water balance
COX 2 enzymes
cause pain and inflammation
Contraindications to ibuprofen
allergy to aspirin, and other NSAID, sulfa (for celecoxib), CVD and HTN- can elevate blood pressure, PUD, renal and hepatic impairment
MOA of acetaminophen
Contraindications of acetaminophen
hepatic dysfunction, alcoholism. Caution with pregnancy and lactation.
Adverse effects of acetaminophen
Overdose of acetaminophpen is responsible for 40% of liver failure
Commonly used in suicide attempts
3-4 grams daily (6 tablets) for a year can cause liver failure
Information from studies including African americans report less pain relief and more side effects with
NSAID and acetaminophen
Disease Modifying Antirheumatic drug
Etancercept (enbrel): genetically engineered TNF receptors are given and react with circulating TNF which is released by activated leukocytes in certain autoimmune conditions (rheumatoid arthritis). Lessens tissue damage.
Gold salts: block action of macrophages which release chemical mediators of inflammation and are phagocytic.Suppress inflammation with arthritis.Toxicity common and many adverse effects.