Chapter 16

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  1. Acetaminophen is NOT an
    anti inflammatory
  2. MOA of Asprin
    inhibit synthesis of prostoglandins (mediator of inflammation) Reduces fever (prostoglandins involved in pyrogenic mechanisms). Also inhibits thromboxane A synthesis which affects platelet aggregation and prostocyclin synthesis which impacts and suppresses platelet aggregation
  3. Uses of asprin
    blood thinner (prevention of secondary heart attack and stroke), sever arthritis
  4. Aspirin is linked to what syndrome? What is it?
    Reyes Syndrome: condition where aspirin and a viral illness combine and it effects ammonia levels in the body causing liver and brain deterioration
  5. Adverse effects of aspirin
    upset stomach, nausea
  6. Aspirin toxicity
    • salicylism-tinnitus
    • hemmorage
    • dizziness
    • confusion
  7. If you are allergic to aspirin, what over the counter pain reliever can you take?
  8. People who are allergic to aspirin cannot take any other non-steroidal anti inflammatory such as
    • naprosyn 
    • ibuprofen
  9. Salicylates prototype
  10. NSAIDS prototype
  11. MOA ibuprofen
    inhiition of prostaglandin synthesis by blocing cyclooxygenase enzymes (COX 1 and COX 2) which are the enzymes that continue progression of inflammation from arachidonionic acid to prostaglandin
  12. COX 1 enzymes
    • blood vessels, stomach, kidneys
    • Necessary for normal blood clotting, protecting stomach lining, and proper sodium and water balance
  13. COX 2 enzymes
    cause pain and inflammation
  14. Contraindications to ibuprofen
    • allergy to aspirin, and other NSAID, sulfa (for celecoxib), CVD and HTN- can elevate blood pressure, PUD, renal and hepatic impairment
  15. MOA of acetaminophen
  16. Contraindications of acetaminophen
    • hepatic dysfunction, alcoholism.  Caution with pregnancy and lactation.  
  17. Adverse effects of acetaminophen
    • Overdose of acetaminophpen is responsible for 40% of liver failure
    • Commonly used in suicide attempts
    • 3-4 grams daily (6 tablets) for a year can cause liver failure 
  18. Information from studies including African americans report less pain relief and more side effects with
    NSAID and acetaminophen
  19. Disease Modifying Antirheumatic drug
    • Etancercept (enbrel):  genetically engineered TNF receptors are given and react with circulating TNF which is released by activated leukocytes in certain autoimmune conditions (rheumatoid arthritis).  Lessens tissue damage.
  20. Antiarthritic Agent
    • Gold salts: block action of macrophages which release chemical mediators of inflammation and are phagocytic.  Suppress inflammation with arthritis.  Toxicity common and many adverse effects.
    • Auranofin (Ridaura)
Card Set:
Chapter 16
2014-02-25 20:26:49
pharmacology exam 2
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