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  1. Kidneys do what?
    • regulate fluid balance
    • electrolyte composition
    • Acid-Base balance
    • Regulate BP
    • Produce red blood cells
  2. something that pass through the glomerus can still be reabsorbed in the proximal and distal tubules

    • water
    • glucose
    • amino-acids
  3. Some ions and large molecules like ________ that were too big to be filtered through the glomerulus can still be filtered out in the _____
    Potassium, Phosphorus, Hydrogen

    Proximal and distal tubules
  4. what is the purpose of Diuretic Therapy?
    increase the rate of urine flow
  5. getting rid of excess fluid can help treat _______
    • HTN
    • heart failure
    • kidney failure
    • liver failure
    • pulmonary edema
    • increased intercranial pressure
    • increased interocular pressure
  6. some examples of LOOP Diuretic are
    • Furosemide (Lasix)
    • Bumetanide (Bumex)
    • Ethacrynic (Edecrin)
    • torsemide (Demadex )
  7. LOOP Diuretis
    Mechanism of action
    blocks the reabsorption of sodium and chloride in the loop of Henle

    Can increase urine flow even when blood flow to kidneys is diminished
  8. How can LOOP Diuretic be given
    • PO
    • IV
    • IM
  9. LOOP Diuretic can move ______ amounts of fluid in a ______ amount of time when given _____
    large amounts of fluid in a short amount of time when given IV
  10. Adverse Effects
    LOOP Diuretics
    • electrolyte imbalance especially K+ (potassium)
    • Dehydration
    • Hypotension
    • Weight Loss
    • Ototoxicity
  11. Drug Interactions
    LOOP Diuretics
    • Digoxin
    • Corticosteriods
    • Lithium
    • Sulfonylureas and insulin
  12. contraindications
    LOOP Diuretics
    • Anurea
    • Hepatic coma
    • fluid and electrolyte depletion
  13. overdose
    loop diuretic

    Replace fluid and electrolyte
  14. Thiazide Diuretics
    • HCTZ
    • Metolazone (Zaroxolyn)
    • Chlorthalidone (Hygroton)
    • Indapamide (Lozol)
    • Methyclothiazide (Enduron)
  15. Mech of Action
    Thiazide Diuretics
    blocks sodium reabsorption and increase K+ (potassium) and water excretion in the distal tubule

    Less effective at producing diuresis than loop diuretics
  16. admin for Thiazide Diuretics
    • PO
    • IV
  17. contraindications
    thiazide diuretics
    • Anurea
    • Pregnancy induced HTN or pre-clamsia
  18. overdose
    thiazide diuretic
    • Hypotension
    • Replace fluid and electrolytes
  19. Adverse Effects
    Thiazide Diuretics
    • Electrolyte imbalance especially K+
    • Dehydration
    • Hypotension
    • Weight Loss
  20. Drug Interactins
    • Digoxin
    • Antihypertensives
    • Antidiabetic drugs, anticoagulants
    • NSAIDS
    • Corticosteroids and amphotericin B
  21. Potassium Sparing Drugs
    • Triamterene (Dyrenium)
    • Amiloride (Midamor)
    • Eplerenone (Inspra)
    • Spironolactone (Aldactone)
  22. potassium sparing diuretics
    Triamterene and Amiloride

    mech of action
    interrupts sodium and potassium in the distal tubule

    causes sodium to stay in the tubule and be excreted in urine and body retains potassium

    Mild diuresis
  23. Potassium sparing


    Mech of Action
    Blocks aldosterone (hormone that enhances the excretion of sodium and the retention of potassium
  24. potassium sparing diuretics

  25. Potassium sparing diuretics

    adverse effects
    • Hyperkalemia
    • Dysrhythmias
    • Dehydration
    • Hyponatrimia
    • Gynecomastia (Spironolactone)
  26. Potassium Sparing diuretics
    • Digoxin
    • Lithium
    • Salicylates (Spironolactone)
    • ACE inhibitors
  27. Contraindications

    Potassium Sparing Diuretics
    • Anuria
    • Hyperkalemia
    • Pregnancy cat C
  28. Overdose
    potassium Sparing Diuretics
    • hypotension
    • Replace Fluid and electrolyte
  29. Misc Diuretics

    Diamox and Neptazine
    inhibit carbonic anhydrase which forms carbonic acid from water and carbon dioxide
Card Set:
2014-03-28 03:37:09
renal cardiac part

renal and cardiac part 1
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