Ch 8 metabolism - Animal Physiology.txt

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rincrocci
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264541
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Ch 8 metabolism - Animal Physiology.txt
Updated:
2014-03-01 17:34:06
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metabolism animal phys
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Ch 8 metabolism - Animal Physiology.txt
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  1. Ch 8
  2. Glycolysis and TCA summary
    • Glycolysis: 2 pyruvic acids generated and 2 NAD reduced to NADH2 for every glucose molecule (net 2ATP)
    • TCA: pyruvic acids lose CO2 and convert NAD to NADH2 to produce Acetyl CoA, which leads to formation of CO2, ATP NADh2 and FADh2 in mitochondria
  3. ETC
    • consists of 4 complexes and these act in reducing and oxidizing.
    • Hydrogens come from complex 1 to UBIQUINONE (lipid soluble molecule in lipid core) and then it becomes reoxidized as it releases electrons to cytochrome b, where electrons are transferred to other cytochromes and finally Oxygen is final Electron Acceptor
  4. Proton pump in oxidative phosphorylation
    • Protons go into mitochondrial matrix during ETC, then must be pumped back out to the OUTER MATRIX, via ATP Synthase
    • ATP Synthase: diffuses protons back to matrix, aiding in generation of ATP
  5. Muscle fatigue causes
    • 1st: glucose from MUSCLE GLYCOGEN fuels ATP production
    • 2nd: muscle depends on glucose from OTHER organs
    • Also lactic acid buildup occurs when pyruvate is used up
  6. Muscle fiber Types (slow and fast twitch)
    • Slow Oxidative (SO): Develop tension slowly bc produce ATP via oxidative pathways -StEADY State catabolism (takes longer vs glycolysis). Low power for long time period. SO can store O2, having more myoglobin, therefore they are more red.
    • Fast glycolytic (FG): Develop fast tension bc they make ATP anaerobically. NON-STEADY state - generate high power for SHORT period of time
  7. Types of Exercise
    • Maximal Exercise: requires maximal rate of O2 consumption
    • SUBmaximal: requires LESS
    • SUPRAmaximal: requires MORE
  8. For oxygen deficit, how do we get ATP
    • Stepwise manner:
    • 1. anaerobic glycolysis
    • 2. phosphagens
    • 3. O2 stores
    • Oxygen is generated from aerobic catabolism from carbohydrate, and can sustain 'pay as you go' but if running marathons, uses lipid sources (less ATP produced vs carbs)
  9. Metabolic Transition
    • Occurs at start and end of exercise
    • OXYGEN DEFICIT: occurs at start
    • EXCESS POSTEXERCISE OXYGEN CONSUMPTION: occurs at the end

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