Chapter 12- Signaling system

Card Set Information

Author:
khaengel
ID:
264937
Filename:
Chapter 12- Signaling system
Updated:
2014-03-09 18:29:35
Tags:
Signaling system
Folders:

Description:
signaling system
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user khaengel on FreezingBlue Flashcards. What would you like to do?


  1. Adhesion Receptors:
    • G-protein class: none
    • Protein kinase type: depends on the pathway
    • Second messenger: none
    • Most phosphorylation on Tyr/Ser/Thr: --
    • Major end response: motility/adhesion
    • Unique element(s): Ligands for receptors are extracellular matrix components.
  2. Gated Ion Channels
    • G-protein class: none
    • Protein kinase type: usually none
    • Second messenger: none
    • Most phosphorylation on Tyr/Ser/Thr: --
    • Major end response: ion moved across membrane.
    • Unique element(s): one system that actually has molecules passing through receptor.
  3. G-protein Couples Receptors
    • G-protein class: heterotrimeric
    • Protein kinase type: PKA or PKC
    • Second messenger: cAMP, DAG, Ca2+, IP3
    • Most phosphorylation on Tyr/Ser/Thr: Ser/Thr
    • Major end response: change in metabolic activity.
    • Unique element(s): All serpentine receptors are in this system. Several different second messengers.
  4. Nuclear Receptors (Steroid Receptors)
    • G-protein class: none
    • Protein kinase type: none
    • Second messenger: none
    • Most phosphorylation on Tyr/Ser/Thr: --
    • Major end response: change in gene expression (+/-).
    • Unique element(s): Receptors in nucleus, ligand passes through membranes.
  5. Receptor Tyrosine Kinases
    • G-protein class: low molecular weight
    • Protein kinase type: Tyr Kinases
    • Second messenger: none
    • Most phosphorylation on Tyr/Ser/Thr: Tyr
    • Major end response: change in metabolic activity or gene expression.
    • Unique element(s): Only type with autophosphorylation, receptor itself has enzyme activity.
  6. Receptor Guanylyl Cyclase
    • G-protein class: Heterotrimeric
    • Protein kinase type: PKG
    • Second messenger: cGMP
    • Most phosphorylation on Tyr/Ser/Thr: Ser/Thr
    • Major end response: change in metabolic activity.
    • Unique element(s): Only systems to use cGMP and Guanylyl cyclase, soluble and membrane receptors.

What would you like to do?

Home > Flashcards > Print Preview