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Norepinephrine (Levophed) Class
sympathomimetic
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Norepinephrine (Levophed) Actions
- 1. peripheral vasoconstriction
- 2. alpha sympathomimetic
- 3. mild beta effects: increase inotropic effects
- 4. increased myocardial oxygen requirements
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Norepinephrine (Levophed) Indications
- 1. hypotension refractory to other sympathomimetic
- 2. Neurogenic shock
- 3. cardiogenic shock
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Norepinephrine (Levophed) Contraindications
- 1. hypotensive states due to hypovolemia
- 2. hypoxia and hypercarbia
- 3. patients taking antidepressents
- 4. do not administer w/ sodium bicarbonate (deactivatd by alkaline solutions)
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Norepinephrine (Levophed) Precautions
- 1. monitor BP
- 2. use large vein for administration
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Norepinephrine (Levophed) Side Effects
- 1. palpitations
- 2. severe hypertension
- 3. local venous irritation and tissue necrosis
- 4. headache, sweating, nausea, vomitting
- 5. ventricular dysrhythmias
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Norepinephrine (Levophed) Dosage
.5-30 mcg / min
Method: 4mg in 500ml D5W giving concentration of 8mcg / min
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Norepinephrine (Levophed) Route
IV infusion only
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Norepinephrine (Levophed) How supplied
ampule: 4mg / 4 ml
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Norepinephrine (Levophed) Pediatric Dosage
.01 - .05 mcg / kg / min (very rare)
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