Nonspecific test, but is elevated during inflammatory response (eg. rheumatoid arthritis, hepatitis, multiple myeloma, etc)
Often run before surgery as an indicator of infection
What is the principle of the ESR procedure?
The rate of erythrocytes settling out of anticoagulated whole blood is measured
↑RBC mass = ↑ESR
↑plasma viscosity = ↓ESR
Describe the ESR procedure in detail
Collect patient blood in EDTA tube (anticoagulant)
Thoroughly mix by inversion (no bubbles)
Using a long-tipped Pasteur pipette fill the sed rate tube by placing the pipette tip in the bottom of the tube (@ 45° angle) and slowly removing the pipette while filling the tube w/ blood meniscus exactly at 0
**LEAVE NO BUBBLES
Place the filled tube in a rack in exact vertical position
Note time and room temperature
After exactly 1 hour read the level the RBCs have settled (do not include buffy coat)
Report results as distance of fall per hour
What are the normal values for the ESR procedure?
Adult female: 0-20mm/hr
Adult male: 0-15mm/hr
What are the possible interferences for the ESR procedure?
Delay in performing the test
Temperature is too high (eg. direct sunlight on tube)
Tube isn't verticle
Vibration or movement
What are the factors that affect the ESR procedure?