What is a proteoglycan aggregate and what is its function?
Proteoglycan aggregates: enormous supramolecular assemblies of many core proteins all bound to a single molecule of hyaluronan. Glycoconjugate, supermolecular complexes. Core protein (aggrecan) + chondroitin sulfate + kerratan sulfate. Its function is to have binding sites for multiple extracellular matrix proteins -> matrix proteins bind to integrins -> cell migration, cell-cell adhesion, and/or signaling.