Thyroid Drugs

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Author:
kyleannkelsey
ID:
266481
Filename:
Thyroid Drugs
Updated:
2014-03-14 18:12:51
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Thyroid Drugs
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Thyroid Drugs
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Thyroid Drugs
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  1. What are the thyroid drugs?
    • Thyroid desiccated
    • Liothyronine
    • Levothyroxine
    • Liotrix
  2. Thyroid desiccated contains which thyroid hormones?
    T3 and T4
  3. Liothyronine contains which thyroid hormones?
    T3
  4. Levothyroxine contains which thyroid hormones?
    T4
  5. Liotrix contains which thyroid hormones?
    T3 and T4
  6. What are the antithyroid drugs?
    Thioamides (methimazole and Propylthiouracil), iodides and Radioactive iodides
  7. Which thyroid drugs are animal derived?
    Thyroid desiccated
  8. Which thyroid drugs are synthetic?
    • Liothyronine
    • Levothyroxine
    • Liotrix
  9. Animal thyroid is what ratio of T4:T3?
    4:1
  10. What are the advantages of animal thyroid hormones?
    Inexpensive and natural
  11. What are the disadvantages of animal thyroid hormones?
    • Variable T3 and T4
    • May degrade (more than synthetics in heat and light)
    • Variation among brands
    • Antigenic
  12. What is the T1/2 of Liothyronine?
    1 day – relatively short for a thyroid hormone
  13. What is the composition of Liothyronine?
    Pure synthetic T3
  14. Does Liothyronine have a fast of slow OOA?
    Fast
  15. What are the disadvantages to Liothyronine?
    • Muliptle daily doses (2-3)
    • Fast, complete absorption = risk of toxicity
  16. What are the advantages of Liothyronine?
    • Known amount of hormone
    • Stable
    • No antigenicity because of purity
    • 4x more potent than T4
  17. What is the DOA of Levothyroxine?
    7 days
  18. What is the composition of Levothyroxine?
    Pure synthetic T4
  19. Does Levothyroxine have a fast of slow OOA?
    Slow
  20. What are the disadvantages to Levothyroxine?
    Different brands have different bioavailability
  21. What are the advantages of Levothyroxine?
    • Known amount of hormone
    • Stable and pure hormone
    • Administer 1 X per day
    • Consistent blood levels, lower peak blood levels
    • Less toxicity
    • Inexpensive
  22. What is the most commonly used Thyroid hormone?
    Levothyroxine
  23. Which drug is a mix of synthetic T3 and T4, but has no therapeutic advantage?
    Liotrex
  24. Why are Thyroid drugs not recommended for people with CV disease?
    • Can increase synthesis of B-receptors in the heart =increased stimulation of heart
    • Increases risk of CAD
  25. What are the adverse effects of all thyroid drugs?
    • Nervousness, Insomnia
    • Palpitations, Angina, Tachycardia
    • Nausea, Diarrhea, Cramps
    • Tremors, weight loss, heat intolerance, sweating
  26. What is the MOA of radioactive iodine in the treatment of HYPERthyroidisim?
    Taken up by follicular cells of the Thyroid and decays, causing destruction of the Thyroid
  27. What is the MOA of Iodides in the treatment of HYPERthyroidisim?
    • High amounts in milligrams (vs. normal in mcgs) inhibit Thyroid peroxidase
    • Reduce Synthesis and Release
  28. What is the MOA of Thioamides in the treatment of HYPERthyroidisim?
    • Inhibit Thyroid peroxidase
    • Reduce T3 and T4 synthesis
  29. What are the Thiamides?
    Methimazole and Propylthiouracil
  30. What are the advantages of Methimazole over Propylthiouracil?
    • More potent
    • Longer DOA = 1x daily dosing
  31. What are the disadvantages of Propylthiouracil compared to Methimazole?
    • Less potent
    • Multiple daily doses required
    • Can cause liver damage
  32. What are Thioamides indicated for?
    • Grave’s disease
    • Normalizing thyroid function before radioactive iodine or surgical removal
  33. What are the adverse effects of Potassium Iodide?
    • Arrhythmias (high K)
    • Confusion and tiredness
    • Dermatitis, rash and joint pain
    • Metallic taste
    • Increased salivation
    • Enlarged salivary glands due to local irritation
  34. What are the advantages of Iodides, like Potassium Iodide?
    • Reduce size and vascularity of the gland
    • Change margin – make more distinguishable
    • Both help with surgery
  35. What are the indications for Potassium iodide?
    • Short term treatment of hyperthyroidism before thyroidectomy
    • Radiation
  36. What hyperthyroid drug can only be used for several weeks before its inhibitory effect wears off?
    Potassium Iodide
  37. What drugs should you give during a Thyroid storm?
    • Propranonol (reduce CV stimulation)
    • Glucocorticoids (CV stabilizing)
    • Iodides (immediate effects)
    • Prpylthiouracil (later effects)
  38. What Antithyroid drug cures Hyperthyroidism?
    Radioactive iodide
  39. What are the adverse effects of Radioactive Iodide?
    • Thyroiditis
    • S/S of Hypothyroidism
    • CI in pregnancy
  40. What are the indications for Radioactive Iodide?
    Grave’s disease
  41. What are the advantages of Radioactive iodide?
    • Curative
    • PO
    • Inexpensive
    • No pain

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