how can prolonged activation of PKC be accomplished?
through the use of phorbol esters
what are the two classes of tyrosine kinases?
receptor tyrosine kinases are transmembrane proteins with an extracellular domain that binds to protein ligands and intracellular catalytic domain that phosphorylates the the relevant substrate proteins.
Non-receptor tyrosine kinases are cytoplasmic or membrane -associated enzymes that are indirectly activated by extracellular signals
where is the inactivated form of CREB usually found in the cell?
it is found attached to its biding site on DNA
what happens when CREB is phosphorylated?
it greatly potentiates transcription
c-fos is regulated by which protein?
True or false, multiple signals converge on c-fos?
what is the purpose of NGF?
it is required for the differentiation, surival, and synaptic connectivity of sympathetic and sensory neurons