Path 342

• is a "new growth" composed of cells...
• originally derived from normal tissues
• that have undergone heritable genetic changes allowing them to become
• relatively unresponsive to normal growth controls and to
• expand beyond their normal anatomic boundaries

• Epithelial neoplasms
• Mesenchymal neoplasms

• Benign tissue: tissue-oma
• and mallignant: tissue-sarcoma

• Fat: lipoma, liposarcoma
• Bone: osteoma, osteosarcoma, etc

• Stratified squamous - skin
• Transitional - bladder, urethra, ureter
• Simple squamous - alveolar, blood vessels
• Simple columnar or cuboidal - GIT
• Psuedostratified columnar with cilia and goblet cells - trachea, nasal passage, bronchi

Stratified squamous and transitional

Simple squmaous, simple columnar or cuboidal, and psuedostratified columnar with cilia and goblet cells

Type of epithelium + papilloma

Type of epithelium + carcinoma

organ + adenocarcinoma

Organ + adenoma

• Benign, non glandular/non secretory
• Malignant, non glandular/non secretory
• Benigan, glandular/secretory
• Malignant, glandular/secretory

• nervous system
• melanocytes
• the adrenal medulla

• Benign: benign melanoma or melanocytoma
• Malignant: malignant melanoma

• Pheochromocytoma
• Benign: pheochromocytoma
• Malignant: malignant pheochromocytoma

• Lining of:
• blood and lymphatic vessels
• serous cavities: peritoneum, pericardium, pleura
• joints

• Bone marrow derived migratory cells:
• lymphocytes
• plasma cells (pregnant B lymphocytes)
• mast cells
• histiocytes (macrophages and dendritic cells)
• They're called round cause they're round!

Lymphoma or lymphosarcoma

Plasma cell tumor

Mast cell tumor

Histiocytic tumore

• common in gonads
• Tumors that contain ecto-, meso- and endodermal elements all of which are neoplastic

• Tumors of embryonic cells
• Since embryonic cells are stem cells, these tumors can form various tissue components

• Hematoma
• Choristoma
• Hamartoma

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Normal tissue in an abnormal location (hair growing from the tongue or cornea)

A tumor-like malformation composed of tissue elements normally found at that site, but which are growing in a disorganized mass

• No metastasis
• Slow, progressive expansion, rare mitotic figures, normal-appearing mitotic figures
• No invasion, cohesive and expansile growth, capsule often present
• Well differentiated appearance, structure similar to tissue or origin, little to no anaplasia

• Frequent metastasis
• Slow-to-rapid growth, erratic growth rate; mitotic figures often numerous; mitotic figures sometimes abnormal
• Local invasion, infiltrative growth, usually no capsule
• Usually some lack of differentiation, structure often atypical, variable degree of anaplasia

• change of place
• Benign neoplasms DO NOT metastasize

• Are evidence of cell division
• In general, the more there are, and the more bizarre they look, the more chance the neoplasm is malignant

• Well-differentiated: tumor cells are more variable in appearance then ones that it arose from, but still recognizable.
• Poorly-differentiated: tumor cells are less easily recognized
• Anaplastic: tumor cells have no resemblance to anything

Tumore cells bear no resemblance to anything.  Their cell of origin cannot easily be determined.