HematologyTest1StemCellsandErythropoiesis

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victimsofadown
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266871
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HematologyTest1StemCellsandErythropoiesis
Updated:
2014-03-18 01:34:55
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Hematology
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HematologyTest1StemCellsandErythropoiesis
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HematologyTest1StemCellsandErythropoiesis
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  1. What are the three modes of cellular proliferation?
    • Constant proliferation (eg skin)
    • Non-proliferation (eg nerve cells)
    • Proliferation on demand
  2. What are the stages of the cell cycle?
    • Resting (G0)
    • Postmitotic (G1)
    • DNA synthesis (S)
    • Premitotic (G2)
    • Mitotic (M)
    • **Generation time (Tg)
  3. What are the stages of blood cell development and differentiation
    • Multipotential stem cell -> unipotential stem cell -> lymphoid -> b / t cells ---> mature b / t cells
    • Multipotential stem cell -> unipotential stem cell -> myeloid -> granulocyte ---> mature granulocytes
    • Multipotential stem cell -> unipotential stem cell -> myeloid -> monocyte / macrophage ---> mature monocyte / macrophage
    • Multipotential stem cell -> unipotential stem cell -> myeloid -> erythroid ---> mature erythrocyte
    • Multipotential stem cell -> unipotential stem cell -> myeloid -> megakaryocyte ---> platelet
  4. Describe the structural and morphological changes that occur during cellular maturation
    • Cell size (reduced w/ maturation)
    • N:C ratio (reduced w/ maturation)
    • Nucleus (present then absent)
    • Nucleolus (present then absent)
    • Chromatin pattern (fine/lace then clumped)
    • Cytoplasm (color)
    • Granulation (present vs absent, color)
  5. What are the specific stages of erythropoeisis (name, alt names, % in body, nucleation, location
    • Rubriblast (pronormoblast, proerythroblast): 0-1%, nucleated, bone marrow
    • Prorubicyte (basophilic normoblast, basophilic erythroblast): 1-4%, nucleated, bone marrow
    • Rubricyte (polychromatophilic normoblast, polychromatophilic erythroblast): 10-20%, nucleated, bone marrow
    • metarubricyte (orthrochromatic normoblast, orthocrhromatic erythroblast): 5-10% nucleated, bone marrow
    • Diffusely basic erythrocyte (polychromatophilic erythrocyte): 1-2%, chromatin/ribosomes, in blood
    • *note - don't call reticulocyte w/o reticulocyte stain
    • Erythrocyte: 98-99%, in blood
  6. Basic physical description of rubriblast
    • Very large
    • dark blue cytoplasm
    • fine chromatin
    • 5:1 N:C
    • Nucleolis
  7. Basic physical description of Prorubricyte
    • Large
    • dark blue cytoplasm
    • fine and coarse chromatin
    • 3:1 N:C
    • nucleolis
  8. Basic physical description of rubricyte
    • medium
    • bluish/pink cytoplasm
    • clumped chromatin
    • 2:1 N:C
    • no nucleolis
  9. Basic physical description of metarubricyte
    • med-small
    • pink/clear cytoplasm
    • clumped chromatin
    • 1:1 N:C
    • no nucleolis
  10. Basic physical description of diffusely basophilic erythrocyte
    • small
    • polychromatophilic/pink cytoplasm
    • no nucleus
  11. What are the names of the stages of abnormal erythrocyte maturation?
    • Promegaloblast
    • Basophilic megaloblast
    • Polychromatic megaloblast
    • Orthrochromatic megaloblast
  12. Describe the various factors that affect the regulation of erythropoiesis
    • Erythropoietin: increases stem cells for RBC development
    • increases hgb synthesis
    • Decreases maturation time
    • Increases bone marrow release of "shift" RBC (reticulocytes)
    • Other requirements: vitamin B12, folic acid, vitamin B6, trace minerals, iron, hormones

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