Card Set Information
What is the 1st line drug for PAD?
What benefits does ACEI have in PAD?
Increases pain free walking
What treatment would you use for a patient with PAD and is Asymptomatic (ABI<0.9)?
ASA 75-325 mg/day
If a PAD patient has Raynaud’s, what drugs are recommended?
Peripheral vasodilatory CCBs = amlopidine or nifedipine
If a patient has Critical leg ischemia, what PAD drugs should you avoid?
BBs (reduce CO further)
What treatment would you use for a patient with symptomatic PAD
: ASA 75-325 mg/day
: Clopidogrel 75 mg/day
High CV risk
: ASA + clopidogrel
What treatment would you use for a patient with Refractory IC PAD?
: cilostazol 100 BID
Potential 2nd line agent
: pentoxifylline 400mg TID
Cilostazol (Pletal) has what MOA?
Suppresses platelet aggregation
Direct artery vasodilator
What are the Adverse effects of Cilostazol (Pletal)?
HA (in 1/3 of patients), diarrhea, edema, palpitations, dizziness, other GI
What are the Contraindications of Cilostazol (Pletal)?
Drug interactions ( CYP3A4 metabolized)
Cilostazol (Pletal) cannot be used in what group of patients?
When should you take Cilostazol (Pletal)?
Take it 30 minutes before or 2 hours after eating
B/c fat increases its absorption
Can Cilostazol (Pletal) be taken with aspirin or clopidogrel?
How do we treat acute critical leg ischemia in PAD?
What dose of UFH would be used for acute critical leg ischemia in PAD?
80 units/kg bolus (max 10,000 units) and 18 units/kg/hr CI (2,300 U/hr max)
After a stent, bypass or angioplasty of PAD, what are the options for treatment?
ASA 81 mg QD and/or Clopidegrel 75 mg/day (1 year)
How should you treat a patient with Asymptomatic PAD?
ASA 81 mg
How should you treat a patient with Symptomatic CAD?
Clopidegrel 75 mg/day
ASA-ER dipyrimadole 25/200 mg BID
ASA 81 mg/day
(In order of presference)