week 8 pam 103

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kevinkuczma
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267538
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week 8 pam 103
Updated:
2014-03-25 16:01:29
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pam103
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pam 103
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  1. Abciximab
    Class
    Glycoprotein IIb/IIIa inhibitor
  2. Abciximab
    Action
    Binds to glycoprotein IIb/IIIa receptors on surface of platelets,  thereby preventing platelet aggregation
  3. Abciximab
    Indication
    Adjunct to percutaneous coronary intervention
  4. Abciximab
    contraindication
    • Internal bleeding (within 6 weeks)
    • GI/GU bleeding, stroke (within two years)
    • Bleeding disorder, recent major surgery (within 6 weeks)
  5. Abciximab
    Precaution
    • should be used with caution in pt with higher risk of bleeding.
    • Allergic reaction have been known to occur
  6. Abciximab
    Side effects
    • Increased rick of bleeding
    • Nausea 
    • Vomiting
    • Abdominal pain 
    • Anemia
    • Pain
    • Swelling
  7. Abciximab
    Dose
    UA/stemi with planed PCI in <24 hours: 0.25 mg/kg IV bolus administered 10-60 min prior to PCI followed by a contunios infushion of 0.125 mcg/kg/min for 12 hours (max dose of 10 mcg/min)
  8. Abciximab
    Route
    IV
  9. Abciximab
    ped dose
    not routinely use
  10. Eptifibatide
    Class
    Glycoprotein IIb/IIIa inhibitor
  11. Eptifibatide
    Action
    Binds to glycoprotein IIb/IIIa receptors on surface of platelets,  thereby preventing platelet aggregation
  12. Eptifibatide
    Indication
    ACS pt undergoing PCI as well as those who will be managed medically
  13. Eptifibatide
    Contraindication
    A history of bleeding diathesis, or evidence of active abnormal bleeding within the previous 30 days

    Severe hypertension (systolic blood pressure > 200 mm Hg or diastolic blood pressure > 110 mm Hg) not adequately controlled

    on anti-hypertensive therapy

    Major surgery within the preceding 6 weeks

    History of stroke within 30 days or any

    history of hemorrhagic stroke

    Current or planned administration of another parenteral GP IIb/IIIa inhibitor

    Dependency on renal dialysis
  14. Eptifibatide
    precaution
    should be used with caution in pt with higher risk of bleeding.
  15. Eptifibatide
    Dose
    • ACS: 180 mcg as a bolus dose, followed by 2 mcg/kg/min dose until discharge or surgery ( upto 72 hours)
    • PCI: 180 mcg/kg as a bolus dose immediate before PCI, followed by 2 mcg/kg/min infusion followed by a second bolus 180 mcg/kg is give 10 min after first bolus. should contune for 18-24 hours (minimum of 12 hours)
  16. Eptifibatide
    route
    IV
  17. Eptifibatide
    ped dose
    not routinely used
  18. Tirofidan
    Class
    Glycoprotein IIb/IIIa inhibitor
  19. Tirofidan
    Action
    Binds to glycoprotein IIb/IIIa receptors on surface of platelets,  thereby preventing platelet aggregation
  20. Tirofidan
    Indication
    ACS
  21. Tirofidan
    Contraindication
    • Internal bleeding (within 6 weeks)
    • GI/GU bleeding, stroke (within two years)
    • Bleeding disorder, recent major surgery (within 6 weeks)
  22. Tirofidan
    Precaution
    • should be used with caution in pt with higher risk of bleeding.
    • Allergic reaction have been known to occur
  23. Tirofidan
    side effects
    • Increased rick of bleeding
    • Nausea 
    • Vomiting
    • Abdominal pain 
    • Anemia
    • Pain
    • Swelling
  24. Tirofidan
    Dose
    0.4 mcg/kg/minfor 30 min continued at 0.1 mcg/kg/min
  25. Tirofidan
    Route
    IV
  26. Tirofidan
    ped dose
    not indicated
  27. Streptokinase
    Class
    Fibrinolytic
  28. Streptokinase
    Action
    Dissolves blood clots
  29. Streptokinase
    Indication
    Acute Myocardial Infraction
  30. Streptokinase
    Contraindication
  31. Streptokinase
    Precautions
    • May be ineffective if administered with in 12 months of prior Streptokinase or anisterplase therapy
    • Anti-arrhythmic and resuceitative meds should be available
  32. Streptokinase
    Side effects
    • Bleeding 
    • Allergic reaction
    • anaphylaxis 
    • fever
    • Nausea and vomiting
  33. Streptokinase
    dose
    1.5 million units over 1 hour
  34. Streptokinase
    route
    IV drip
  35. Streptokinase
    ped dose
    not recommend

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