Pharm 2

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Author:
MeganM
ID:
268238
Filename:
Pharm 2
Updated:
2014-03-28 20:46:23
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Pharm
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TAMHSC
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Pharm 2
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  1. GH is used in the management of growth failure in children due to what?
    • deficiency,
    • chronic renal insufficiency
  2. What is GH used to manage (mostly in adults)?
    • short stature associated with Turners syndrome
    • AIDS
    • Short bowel syndrome
    • GH deficiency
  3. What drug is used for underproduction of GH?
    Somatropin
  4. Adverse effects of Somatropin.
    • Hyperglycemia & insulin resistance
    • Edema of hands/feet
    • H/A & HTN initially but resolve
  5. Contraindications of GH.
    • children w/ epiphiseal closure
    • w/ corticosteroids
    • caution w/ severe renal & hepatic disease
    • DM
  6. Drug given for overproduction of GH.
    Ocreotide
  7. Adverse rxns of Ocreotide.
    • GI systems
    • elevated LFTs
    • immediate yellowing of skin or sclera
    • RUQ pain
  8. Contraindications of Ocreotide.
    • caution w/ renal impairment or failure
    • liver & cardiac disease
    • DM
    • hypothyroidism
  9. What does Ocreotide do in addition to the natural hormone?
    suppresses stomach bleeding and GI secretions
  10. Most common cause of hypothyroidism.
    Hashimoto's thyroiditis
  11. What two facters characterize hypothyroidism?
    • 1. hypometabolic state
    • 2. myxedematous changes in body
  12. What is myxedema?
    • An extreme complication of hypOthyroidism.
    • a mucous type of edema caused by an accumulation of fatty substances in CT
  13. Characteristics of hypometabolic state.
    • gradual onset of weakness & fatigue
    • wt gain & decreased appetite
    • GI motility slowing = constipation
    • mental dullness, decreased memory, slow reflexes
  14. Myxedematous changes in the body.
    • fluid accumulation 
    • puffy eyes
    • enlarged tongue
  15. mechanism of axn for Levothyroxine.
    increases metabolic rate
  16. The key in dosing Levothyroxine.
    "low & slow"
  17. Med for hypothyroidism.
    Levothyroxine
  18. Most common cause of hyperthyroidism.
    Grave's disease
  19. Most visible signs of hyperthyroidism.
    • goiter
    • exopthalmus
  20. Three classes of steroids.
    • Mineralocorticoids (Aldosterone 95%)
    • Glucocorticoids (cortisol)
    • Gonadocorticoids
  21. Things to report with corticosteroid drugs.
    • wt gain > 1 kg in 24 hrs or >2kg in a week
    • BP >140/90
    • tachycardia
  22. What side effects would you see with corticosteroid use due to increased fluid retention?
    • increased BP
    • HTN
    • tachycardia
  23. Dosing for hydrocortisone.
    • PO: 10-320 mg/day, 3-4 divided doses
    • IV/IM: 15-800 mg/day, 3-4 divided doses
    • max = 2g/day
  24. Adverse effects of LONG-term corticosteroid use.
    • Cushings Syndrome:
    •  suppresses immune system = increased risk for infection
    •  peptic ulcers (esp w/ NSAIDS)
    •  osteoporosis
    •  nervousness, moodiness, hallucinations
    •  cataracts & glaucoma
    •  myopathy
    •  HYPERglycemia
    •  HYPERlipidemia
    •  HYPERnatremia
    •  HYPOkalemia
    • Edema, HTN
  25. Adverse effects of vasopressin.
    • necrosis & gangrene
    • water intox
  26. What is vasopressin used to treat?
    • central or neurogenic DI (IM or SQ)
    • alternative to epinephrine (IV)
    •     esophageal or upper GI bleeding
    •     cardiac arrest
    •     severe hypotension or shock

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