Causes a normocytic normochromic anaemia.
Can be hereditary. Spherocytosis, elliptocytosis, G6PD deficiency, pyruvate kinase deficiency, sickle cell anaemia.
Or can be acquired. Autoimmune, alloimmune, drug associated, infections (malaria, clostridia), March haemoglobinuria, red cell fragmentation (prostethic heart valves, microangiopathic haemolysis), paroxysmal nocturnal haemoglobinuria, chemical & physical agents, secondary to liver or renal disease.
Presents with features of anaemia, jaundice, splenomegaly, pigment gall stones.