Female repro 1

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Author:
Neda317
ID:
269165
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Female repro 1
Updated:
2014-04-18 02:05:52
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    • •Acute suppurative salpingitis
    •     –Lumen filled with purulent exudate
    • Extra-mammary Paget Disease
    • •On labia majora
    • mucin +
  1. Bartholin cysts
    • Condyloma Acuminatum
    • fibrous stromal perinuclear halo --> koilocyte 
    • HPV 6-11
  2. Condyloma Acuminatum
    • Vulvar intra-epithelial neoplasia (VIN)
    • •Pre-malignant, intra-mucosal squamous neoplasm
    • •Frequently precedes invasive carcinoma
    • •Classic VINs
    • –Bowen disease (CA in situ); HPV 16
    • –Multicentric, marked nuclear atypia
    • •Differentiated (simplex) VINs
    • –HPV negative
    • –Associated with lichen sclerosis or lichen simplex chronicus
    • –Post-menopausal
    • –Basal atypia, abnormal keratinization---- well diff CA
  3. Squamous cell carcinoma -Vulva
    • Malignant Melanoma
    • –Reactivity with antibodies to S-100 protein

    • –Absence of reactivity with
    • antibodies to CEA

    –Lack of muco-polysaccharides

    •Both are present in Paget disease 
    • Malignant Melanoma
    • –Reactivity with antibodies to S-100 protein

    • –Absence of reactivity with
    • antibodies to CEA

    –Lack of muco-polysaccharides

    •Both are present in Paget disease
    • Adenocarcinoma of vagina
    • clear cell adenocarcinomas in young women whose mothers had
    • been treated with diethylstillbestrol (DES) during pregnancy (for a threatened
    • abortion)
  4. Infants and children

    •    
    • < 5 years

    • Sarcoma botryoides grape like clusters
    • small cell w oval nuclei  


    • Vagina - Embryonal
    • Rhabdomyosarcoma
  5. Cervicitis 
  6. Endo-cervical polyp

    • •Benign
    • tumors

    • •Connective
    • tissue stroma


    • •Dilated
    • glands
  7. CIN 1
  8. CIN 2
    • CIN 3
    • •Increased expression of p16 by viral oncogenes
  9. CIN 3
  10. Squamous cell carcinoma

    •Fungating (exophytic)

    •Ulcerating

    •Infiltrative cancer
    • •Squamous cell carcinomas
    • Keratinized 
    • •Squamous cell carcinomas
    • non-keratinized
  11. Chronic endometritis
    • Endometriosis
    • Dx: –Aromatase cytochrome P450
  12. Endometriosis

    • •Definitive diagnosis
    • (2 of the 3 features)

    • –Endometrial glands
    • in ectopic lesion

    • –Stroma in
    • ectopic lesion

    • –Hemosiderin
    • pigment in ectopic lesion
  13. Endometriosis
  14. Adenomyosis

    Dx: Endometrial stroma and glands in the myometrium.

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