female repro 3

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  1. Brenner Tumor 

    • Adenofibromas, unilateral, 
    • –Nests of transitional cells ~ urinary bladder

    –Fibrous stroma ~ normal ovary
  2. Mature (Benign) Teratomas
    • Mature (Benign) Teratomas
    • •known as dermoid cysts

    •Origin: Ectodermal differentiation of totipotential cells

    •Age: In young women during active reproductive years
  3. Immature (Malignant) Teratomas

    • –In pre pubertal adolescents and young women
    • Varying amounts of immature tissue
    • differentiating toward cartilage, glands, bone, muscle and nerves
  4. Monodermal or Specialized Teratomas

    • Struma ovarii: Composed of thyroid tissue: Can be functional leading to hyperthyroidism
    • Carcinoid 
    • •Origin- Intestinal epithelium in a teratoma

    •Produces 5-OH-tryptamine

    • •Causes carcinoid
    • syndrome
  5. Dysgerminoma

    •All dysgerminomas are malignant

    •Half of malignant germ cell tumors

    •Age–In childhood
    • Dysgerminoma
    • •PLAP bc counterpart of seminoma of testis
    • •inc. HCG 
    • •associated with Turner Syndrome
  6. Endodermal Sinus (Yolk Sac) Tumors

    • •2nd most common malignant tumor of germ cell origin
    • •Rich in alpha-fetoprotein and alpha1-antitrypsin
    • •Schiller-duval body
    • •Glomerulus like structure
    • Granulosa -Theca Cell Tumors
    • •postmenopausal women
    • •Yellow coloration Hormonally
    • active tumors; produced by contained lipids
    • Granulosa -Theca Cell Tumors
    • •Granulosa cell component

    • •Call-Exner bodies Can elaborate large
    • amounts of estrogen

    Chances of malignancy in granulosa cell forms

    Elevated tissue/serum levels of inhibin
    • Sertoli-Leydig Cell Tumors (Androblastomas,
    • Arrhenoblastoma)
    • •Is androgen secreting

    •Symptoms of virilization (masculinization)

    •C/S- Characteristic yellow-tan color
    • Tumors Metastatic to ovary
    • •Krukenberg tumors
  7. •Krukenberg tumors
    • Complete Mole
    • •No fetal parts are identified
    • Complete Mole
    • •No fetal parts are identified
    • Partial Mole
    • •Pathogenesis
    • –Triploid (69,XXY) or tetraploid (92,XXXY)
    • Uterine cavity filled with a
    • delicate, friable mass of thin-walled, translucent, cystic, grapelike
    • structures [ swollen edematous (hydropic) villi]
  8. Partial Mole
    • Choriocarcinoma
    • •Epithelial malignant neoplasm of trophoblastic cells
    • –Large pale areas of ischemic
    • necrosis
    • Choriocarcinoma
    • •Titers of HCG
  9. Placental site trophoblastic tumor

    –Beta HCG levels may be high

    –Biomarkers (Mel-Cam and Ki-67) detect increased proliferation in trophoblastic cells

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female repro 3
2014-04-18 06:46:55
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