Avamys CPI

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Author:
NinaTolentino
ID:
269288
Filename:
Avamys CPI
Updated:
2014-04-05 03:13:38
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Avam
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Description:
Avamys CPI
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  1. Avamys has ______ actuation per spray
    27.5mcg
  2. True or False
    Fluticasone furoate is a synthethic trifluorinated corticosteroidtp that possess a very high affinity for the glucocorticoid receptor and has a potent anti-inflammatory actions
    True
  3. True or False

    The plasma protein binding of Fluticasone furoate is lesser than 99%. Fluticasone furoate is widely distributed with volume of distribution at steady state of, on average 608L.
    False. greater than
  4. Avamys is indicated for the treatment of the nasal symptoms _____________
    And ocular symptoms ____________ 
    Of perennial allergic rhinitis in  adults and adolescents.
    • Nasal symptoms
    • Rhinorrhea
    • Nasal congestion
    • Nasal itching
    • Sneezing
    • Ocular symptoms
    • Itchin/burning
    • Tearing/ watering
    • Redness of the eye
  5. True or False

    Avamys is indicated for children in the treatment of the nasal symptoms of seasonal and perennial allergic rhinitis
    True
  6. True or False
    Elimination was primarily via the fecal route.
    True
  7. True or False
    Fluticasone furoate nasal spray ia a  white, uniform suspension contained in a clear glass bottle, fitted witha metering atomising spray pump
    • False 
    • Amber bottle
  8. True or False
    No dosage adjusment for elderly patients
    True
  9. True or False

    No dosage adjustment is required  for patient with renal impairment.
    True
  10. True or False

    No dosage adjustment is required for patient eith hepatic impairment
    • True 
    • For patient with mild to moderate hepatic impairment. There are no data in patients with severe hepatic impairment
  11. What is the very common adverse effect of Fluticasone furoate?
    Epistaxis
  12. What is the common adverse effect of Fluticasone furoate?
    Nasal ulceration
  13. True or False
    Fluticasone furoate is rapidly cleared by extensive firstpass metabolism mediated by cytochrome P 450 3A4
    True
  14. Fluticasone furoate onset of action has been observed as early as?
    8 hours
  15. The recommended starting dose of Fluticasone furoate for children 2 -11 yrs old is?
    1 spray in each nostrils once a day
  16. The recommended starting dose of Fluticasone furoate is _____ for adults and adolescents
    2 sprays per nostrils once a day
  17. True or False

    Children not adequately responding to 1 spray in each nostrils may use 2 sprays?
    True
  18. True or False
    Fluticasone furoate is recommended for patients  under 2 years old
    • False
    • There are no data to recommend Fluticasone furoate for children under 2yrs old
  19. True or False
     In a bioavailability study, intranasal doses up to 24 times the recommended daily adukt dose were studied over 3 days with no adverse systemic effects observed.
    True
  20. Fluticasone furoate sould store at what condition?
    Not exceeding 30C. Do not refrigerate
  21. True or False

    Fluticasone furoate should be primed before use and re-primed if the cap is left off or the device does not seem to be working.
    True
  22. How many seconds should Fluticasone furoate needs to be shaken vigorously with the cap on?
    10 seconds
  23. True or False

    The cap must be replaced after use to keep the nozzle clean and to prevent the need for re priming.
    True
  24. True or False

    Removable cap protects the nozzle from dust  and prevents it from blocking up, seals in the pressure. When the cap is in place the button on the side cant be  pressed accidentally
    True
  25. True or False

    Fluticasone furoate is very thick and becomes more liquid when you shake it well. It will only spray when it becomes liquid
    True

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