thera test 2 parenteral admixtures

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Author:
coal
ID:
269628
Filename:
thera test 2 parenteral admixtures
Updated:
2014-04-07 15:47:43
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thera test parenteral admixtures
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thera test 2 parenteral admixtures
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thera test 2 parenteral admixtures
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  1. 5 consequences of incompatability
    • reduction in
    •   potency
    •   shelf-life
    •   beyond use date
    •   utilization time
    •   active drug available for delivery
  2. 4 basic principles of incompatibility
    • concentration-dependent precipitation
    • acid-base reactions
    • change in physical state of products
    • change in protonation-deprotonation equilibrium
  3. USP 797 allowable degradation
    10%
  4. 5 things physical incompatabilities may cause
    • phase separation
    • precipitation (most common)
    • change in color or viscosity
    • effervescence
    • formation of immiscible liquid layers
  5. 4 container interactions
    • adsorption
    • absorption
    • leaching
    • filters
  6. 4 types of chemical degradation
    • photolysis
    • hydrolysis
    • oxidation & reduction
    • racemization
  7. 3 factors that influence chemical degradation rates
    • pH
    • temperature
    • drug concentration
  8. 4 consequences for the patient due to incompatibility issues
    • damage from toxic products
    • particulate emboli from crystallization & separation
    • tissue irritation due to major pH changes
    • therapeutic failure

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