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2014-04-08 16:27:20
Clinical Immunology Exam

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  1. A cold agglutinin is performed. The results are as follows:

    The patient's titer is _____
  2. In an immunoassay, serum is added to a microtiter well coated with specific antibody. After incubation and washing, enzyme-labeled specific antibody is added. This procedure is:
    sandwich immunoassay
  3. The principal demonstrable antibody in SLE is antibody to:
    nuclear antigen
  4. Which two organs are considered the primary lymphoid organs where immunocompetent cells originate and mature?
    thymus and bone marrow
  5. What type of B cells are formed after antigen stimulation?
    Plasma cells and memory cells
  6. Which CD marker appears during the first stage of T cell development and remains present as an identifying marker for T cells?
  7. How are cytotoxic T cells and natural killer cells similar?
    effective against virally infected cells
  8. Which region of the immunoglobulin molecule can bind antigen?
  9. Which immunoglobulins help initiate the classic complement pathway?
    IgG and IgM
  10. All of the following are immunologic functions of complement except:
    induction of an antiviral state
  11. The detection of precipitation reactions depends upon the presence of maximal proportions of antigen and antibody. A patient's sample contains a large amount of antibody, but the reaction in a test system containing antigen is negative. What has happened?
    prozone phenomenon
  12. What comprises the reaction system in an enzyme linked immunosorbent assay?
    enzyme-conjugate + substrate + chromogen
  13. Which test is most likely to be positive in the tertiary stage of syphilis?
  14. RF correlates with all of the following except:
    Age of patient
  15. What is the most likely explanation when antibody tests for HIV are negative, but a polymerase chain reaction test performed 1 week later is positive?
    Patient is in the window phase before antibody production
  16. An antistreptolysin - O neutralization test was performed on the serum from a 5 year old female. The results.... Assuming that all controls were acceptable, the patient's titer is:
    625 500 333 ????
  17. The most reliable immunologic test for S. pyogenes infection is:
    Anti- NADase
  18. What is the most likely explanation when a patient has clinical signs of viral hepatitis but tests are negative for hepatitis markers?
    the patient may be in the core window
  19. Which of the hepatitis markers is the initial detectable marker found in serum during the incubation period of HBV infection?


    Both b and c (HBsAg and Anti-HBs) ???
  20. In the indirect fluorescent antinuclear antibody test, a homogenous pattern indicates the presence of antibody to:
  21. The immunoglobulin class associated with immediate hypersensitivity or atopic reactions is:
  22. Which of the following is the C3 activation unit in the classical complement pathway?
  23. Which of the following terms describes a graft between genetically unidentical individuals belonging to the same species?
  24. T lymphocytes are incapable of functioning as
    phagocytic cells
  25. Antinuclear antibody test result of a speckled pattern indicates which of the following antibodies?
    antibody to any extractable nuclear antigen devoid of DNA of histone
  26. Which of the following describes an antigen-antibody precipitation reaction of nonidentity?
    Precipitin lines cross, forming double spurs
  27. The component associated only with the alternative pathway of complement activation is:
    Properdin factor B
  28. Which of the following statements about immunoglobulins is true?
    IgA class exist as serum and secretory molecules
  29. A positive ANA with a pattern of anticentromere antibodies is most frequently seen in patients with:
    CREST syndrome
  30. Antihistamines:
    Block histamine receptors